Pathophysiological basis of specific immunotherapy

Marek Jutel

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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3/2003
vol. 20

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abstract:

Pathophysiological basis of specific immunotherapy

Marek Jutel

Post Derm Alerg 2003: XX, 3, 125-129

Online publish date: 2003/06/26

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Specific allergen immunotherapy restores normal peripheral tolerance, which appears in healthy individuals. The basic role in this process is played by allergen specific T cells. The shift of functional phenotype of specific T cells results from the suppression and following reactivation step. The suppression of specific T cells is due to the activation of allergen specific regulatory CD4+CD25+ T cells. Cytokines produced by particular population of lymphocytes play the basic role in the regulation of immunoglobuline synthesis and activation of effector cells. Thus SIT modulates both humoral and cellular component of allergic inflammation.

keywords:

Pathophysiological basis of specific immunotherapy

Marek Jutel

specific immunotherapy, pathomechanism