eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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2/2008
vol. 7
 
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abstract:

The ERCC4/XPF gene polymorphism in postmenopausal women with breast cancer

Anna Sobczuk
,
Beata Smolarz
,
Hanna Romanowicz-Makowska
,
Tomasz Pertyński

Przegląd Menopauzalny 2008; 2: 81–84
Online publish date: 2008/04/28
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Background: The ERCC4/XPF gene plays an important role in the DNA repair system.
Objective: Arg415Gln polymorphism in the ERCC4/XPF gene in postmenopausal women with breast cancer was analysed. Material and methods. Blood samples were obtained from 100 women with breast cancer and controls (n=106). The polymorphisms were determined by PCR-RFLP.
Results: The distribution of the genotypes of the Arg415Gln polymorphism of ERCC4/XPF in both controls and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences (p>0.05) in genotype distributions or allele frequencies between subgroups assigned to histological stage.
Conclusion: The results suggest that Arg415Gln polymorphism in ERCC4/XPF may not be linked with appearance and development of breast cancer.
keywords:

breast cancer, DNA repair genes, gene polymorphism, ERCC4/XPF
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