Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population

Michał Sobjanek; Monika Zabłotna; Magdalena Dobosz-Kawałko; Igor Michajłowski; Wioletta Mędrzycka-Dąbrowska; Roman Nowicki; Małgorzata Sokołowska-Wojdyło

doi:10.5114/pdia.2014.44004

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

5/2015
vol. 32

Send email

Copy url:

abstract:

Original paper

Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population

Michał Sobjanek

,

Monika Zabłotna

,

Magdalena Dobosz-Kawałko

,

Igor Michajłowski

,

Wioletta Mędrzycka-Dąbrowska

,

Roman Nowicki

,

Małgorzata Sokołowska-Wojdyło

Postep Derm Alergol 2015; XXXII (5): 323–326

DOI: https://doi.org/10.5114/pdia.2014.44004

Online publish date: 2015/10/29

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Sobjanek M, Zabłotna M, Dobosz-Kawałko M, et al. Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2015;32(5):323-326. doi:10.5114/pdia.2014.44004.

APA

Sobjanek, M., Zabłotna, M., Dobosz-Kawałko, M., Michajłowski, I., Mędrzycka-Dąbrowska, W.,  & Nowicki, R. et al. (2015). Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 32(5), 323-326. https://doi.org/10.5114/pdia.2014.44004

Chicago

Sobjanek, Michał, Monika Zabłotna, Magdalena Dobosz-Kawałko, Igor Michajłowski, Wioletta Mędrzycka-Dąbrowska, Roman Nowicki,  and Małgorzata Sokołowska-Wojdyło. 2015. "Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 32 (5): 323-326. doi:10.5114/pdia.2014.44004.

Harvard

Sobjanek, M., Zabłotna, M., Dobosz-Kawałko, M., Michajłowski, I., Mędrzycka-Dąbrowska, W., Nowicki, R.,  and Sokołowska-Wojdyło, M. (2015). Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 32(5), pp.323-326. https://doi.org/10.5114/pdia.2014.44004

MLA

Sobjanek, Michał et al. "Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 32, no. 5, 2015, pp. 323-326. doi:10.5114/pdia.2014.44004.

Vancouver

Sobjanek M, Zabłotna M, Dobosz-Kawałko M, Michajłowski I, Mędrzycka-Dąbrowska W, Nowicki R et al. Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2015;32(5):323-326. doi:10.5114/pdia.2014.44004.

Introduction: The pathogenesis of acne is complex, multifactorial and not well understood. The genetic background of this dermatosis is well documented.

Aim: To assess the frequency of –34 T>C single nucleotide polymorphism in the promoter of the CYP17 gene as well as m1 (+6,235 T>C) and m² (+4,889 A>G) mutation in the coding region CYP1A1 gene acne patients from the Northern Polish population.

Material and methods: The study included 115 acne patients and 94 healthy controls (aged over 20) without acne in anamnesis. The CYP1A1 polymorphism was analyzed by polymerase chain reaction (PCR). The restriction fragment length polymorphism (RFLP) was used to analyze m1 mutation and allele-specific PCR in the case of m² mutation. The CYP17 polymorphism was analyzed by RFLP. The results were evaluated by the Pearson’s c2 test.

Results: There were no statistically significant associations between allele and genotype frequencies between the acne and the control group.

Conclusions: We did not confirm the role of the CYP1A1 and CYP17 gene as predictor factors for acne development in the Polish population.

keywords:

Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population

Michał Sobjanek , Monika Zabłotna , Magdalena Dobosz-Kawałko , Igor Michajłowski , Wioletta Mędrzycka-Dąbrowska , Roman Nowicki , Małgorzata Sokołowska-Wojdyło

acne, genetic factors, cytochrome P-450, CYP1A1, CYP17, gene polymorphism

Michał Sobjanek

,

Monika Zabłotna

,

Magdalena Dobosz-Kawałko

,

Igor Michajłowski

,

Wioletta Mędrzycka-Dąbrowska

,

Roman Nowicki

,

Małgorzata Sokołowska-Wojdyło