Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct

Vor Luvira; Supot Kamsa-ard; Ake Pugkhem; Varisara Luvira; Tharatip Srisuk; Attapol Titapun; Artit Silsirivanit; Sopit Wongkham; Narong Khuntikeo; Chawalit Pairojkul; Vajarabhongsa Bhudhisawasdi

doi:10.5114/ceh.2019.87641

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

Current issue Archive Manuscripts accepted About the journal Editorial board Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

3/2019
vol. 5

Send email

Copy url:

abstract:

Original paper

Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct

Vor Luvira

¹

,

Supot Kamsa-ard

²

,

Ake Pugkhem

¹

,

Varisara Luvira

¹

,

Tharatip Srisuk

¹

,

Attapol Titapun

¹

,

Artit Silsirivanit

¹

,

Sopit Wongkham

¹

,

Narong Khuntikeo

¹

,

Chawalit Pairojkul

¹

,

Vajarabhongsa Bhudhisawasdi

¹

Faculty of Medicine, Khon Kaen University, Thailand
Faculty of Public Health, Khon Kaen University, Thailand

Clin Exp HEPATOL 2019; 5, 3: 250–255

DOI: https://doi.org/10.5114/ceh.2019.87641

Online publish date: 2019/09/05

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Luvira V, Kamsa-ard S, Pugkhem A, et al. Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct. Clinical and Experimental Hepatology. 2019;5(3):250-255. doi:10.5114/ceh.2019.87641.

APA

Luvira, V., Kamsa-ard, S., Pugkhem, A., Luvira, V., Srisuk, T.,  & Titapun, A. et al. (2019). Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct. Clinical and Experimental Hepatology, 5(3), 250-255. https://doi.org/10.5114/ceh.2019.87641

Chicago

Luvira, Vor, Supot Kamsa-ard, Ake Pugkhem, Varisara Luvira, Tharatip Srisuk, Attapol Titapun,  and Artit Silsirivanit et al. 2019. "Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct". Clinical and Experimental Hepatology 5 (3): 250-255. doi:10.5114/ceh.2019.87641.

Harvard

Luvira, V., Kamsa-ard, S., Pugkhem, A., Luvira, V., Srisuk, T., Titapun, A., Silsirivanit, A., Wongkham, S., Khuntikeo, N., Pairojkul, C.,  and Bhudhisawasdi, V. (2019). Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct. Clinical and Experimental Hepatology, 5(3), pp.250-255. https://doi.org/10.5114/ceh.2019.87641

MLA

Luvira, Vor et al. "Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct." Clinical and Experimental Hepatology, vol. 5, no. 3, 2019, pp. 250-255. doi:10.5114/ceh.2019.87641.

Vancouver

Luvira V, Kamsa-ard S, Pugkhem A, Luvira V, Srisuk T, Titapun A et al. Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct. Clinical and Experimental Hepatology. 2019;5(3):250-255. doi:10.5114/ceh.2019.87641.

PlumX metrics:

Aim of the study
Intraductal papillary neoplasm of the bile duct (IPNB) can present at various stages of the disease. Each stage needs different treatment. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been described as predictive markers for several tumors. There has been no investigation on the role of NLR and PLR in IPNB.

Material and methods
We retrospectively reviewed the medical records of 112 patients who underwent curative-intent hepatic resection for IPNB between January 2007 and December 2011. All clinical parameters and survival were analyzed for their association with NLR and PLR.

Results
For prediction of malignancy, the best respective cut-off for NLR and PLR was 2.74 and 130, with area under the ROC curve being 0.662 and 0.763. For micro-papillary IPNB, both markers well predict malignancy and lymph node involvement. The respective area under the ROC curve of NLR and PLR for prediction of malignancy was 0.78 and 0.88. Both markers had an area under the ROC curve for prediction of lymph node involvement of 1.0. The median overall survival of those with PLR < 130 was 86.4 months compared with 45.0 months for those with PLR > 130 (p = 0.02).

Conclusions
NLR and PLR seem likely candidates for predicting malignancy, lymph node involvement, and survival of the patients. PLR performed better than NLR for all predictions. The markers worked very well for micro-papillary IPNB; however, we recommend using these markers in conjunction with the radiologic appearance of tumors.

keywords:

Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct

Vor Luvira 1 , Supot Kamsa-ard 2 , Ake Pugkhem 1 , Varisara Luvira 1 , Tharatip Srisuk 1 , Attapol Titapun 1 , Artit Silsirivanit 1 , Sopit Wongkham 1 , Narong Khuntikeo 1 , Chawalit Pairojkul 1 , Vajarabhongsa Bhudhisawasdi 1

intraductal papillary neoplasm of the bile duct, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, predictive marker

Vor Luvira

¹

,

Supot Kamsa-ard

²

,

Ake Pugkhem

¹

,

Varisara Luvira

¹

,

Tharatip Srisuk

¹

,

Attapol Titapun

¹

,

Artit Silsirivanit

¹

,

Sopit Wongkham

¹

,

Narong Khuntikeo

¹

,

Chawalit Pairojkul

¹

,

Vajarabhongsa Bhudhisawasdi

¹