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ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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3/2020
vol. 19
 
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abstract:
Original paper

Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus

Giampaolo Mainini
1
,
Mario Passaro
2
,
Antonio Schiattarella
3
,
Pasquale De Franciscis
3
,
Mariano C. Di Donna
4
,
Gennaro Trezza
5

  1. Menopausal Center, San Leonardo Hospital, ASL NA3 SUD, Castellammare di Stabia, Naples, Italy
  2. ASL NA3 SUD, Naples, Italy
  3. Unit of Gynecology and Obstetrics, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
  4. Department of Gynecologic Oncology, Arnas Civico, University of Palermo, Palermo, Italy
  5. Unit of Gynecology and Obstetrics, Rummo Hospital, Benevento, Italy
Menopause Rev 2020; 19(3): 130-134
DOI: https://doi.org/10.5114/pm.2020.99567
Online publish date: 2020/10/02
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Introduction
To evaluate the efficacy of a nutraceutical compound containing Uticlin® (D-mannose, cranberry, bearberry, Olea europaea), inulin, Orthosiphon and Lactobacillus acidophilus, in preventing recurrent urinary tract infections (UTIs) in menopausal women.

Material and methods
This was a prospective cohort study of menopausal women recruited with a history of recurrent UTIs in the previous twelve months and who intended to treat their bladder problem without the use of antibiotics and/or anti-inflammatories. Women were proposed the use of an oral nutraceutical compound. The drug was taken for ten days, every month. Women were assigned to two parallel cohorts: patients using (group 1) or not using (group 2) this nutraceutical compound. The primary objective of the study was to evaluate the number of women with less than two infective episodes in the 6-month follow-up and less than three episodes in the 12-month follow-up. The secondary endpoints were to evaluate the reduction of related symptoms at 12-month follow-up, according to the Visual Analog Scale (VAS).

Results
At 6 months of therapy, the reduction in the number of patients with ≥ 2 UTIs was statistically significant (p < 0.05) compared to baseline only in group 1. At 12 months, the number of patients who were disease-free was significantly higher (p < 0.05) in group 1 compared to group 2. Moreover, the improvement of related symptoms was statistically significant (p < 0.05) in group 1, as shown by the reduction in the VAS scale value.

Conclusions
In menopausal women, the combination of D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus SGL 11 per os represents a useful therapy for recurrent UTIs in women wanting a natural approach.

keywords:

menopause, cystitis, urinary tract infections, UTIs, D-mannose, nutraceutical
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