eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
2/2000
vol. 4
 
Share:
Share:
abstract:

Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression

Fiebo J.W. ten Kate
,
G. Johan A. Offerhaus
,
Hugo Obertop
,
J. Jan B. van Lanschot
,
Johanna W. van Sandick
,
Wojciech Polkowski

Współcz Onkol (2000) vol. 4, 2 (68-71)
Online publish date: 2003/07/25
View full text Get citation
 
The aim of this study was to investigate the prognostic significance of the Laurén classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and/or gastro-esophageal junction (GEJ). Forty-one adenocarcinomas of the esophagus and/or GEJ were reviewed for tumor stage, Laurén classification, and c-erbB-2 by immunohistochemistry. According to the Laurén classification, tumors were classified as intestinal, mixed, or diffuse in 54%, 32%, and 15%, respectively. Diffuse tumors had a significantly worse prognosis than intestinal tumors. The prognostic value of the Laurén classification was independent of stage. C-erbB-2 overexpression was detected in 24% of the tumors and was present exclusively in intestinal tumors and in intestinal-type areas of mixed tumors. Ten of the 30 stage III/IV tumors were c-erbB-2 positive, while none of the 11 stage I/II tumors overexpressed the oncogene product.



Conclusions:

1) the Laurén classification is independent prognostic factor in adenocarcinoma of the esophagus and GEJ,

2) intestinal and diffuse tumors differ oncogenetically,

3) c-erbB-2 overexpression is associated with stage of disease.
keywords:

Adenocarcinoma of the esophagus, Laurén classification, oncogenes, suergery, prognosis

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.