Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression

Fiebo J.W. ten Kate; G. Johan A. Offerhaus; Hugo Obertop; J. Jan B. van Lanschot; Johanna W. van Sandick; Wojciech Polkowski

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2000
vol. 4

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abstract:

Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression

Fiebo J.W. ten Kate

,

G. Johan A. Offerhaus

,

Hugo Obertop

,

J. Jan B. van Lanschot

,

Johanna W. van Sandick

,

Wojciech Polkowski

Współcz Onkol (2000) vol. 4, 2 (68-71)

Online publish date: 2003/07/25

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AMA

J.W. ten Kate F, Johan A. Offerhaus G, Obertop H, Jan B. van Lanschot J, W. van Sandick J, Polkowski W. Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression. Contemporary Oncology/Współczesna Onkologia. 2000;4(2):68-71.

APA

J.W. ten Kate, F., Johan A. Offerhaus, G., Obertop, H., Jan B. van Lanschot, J., W. van Sandick, J.,  & Polkowski, W. (2000). Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression. Contemporary Oncology/Współczesna Onkologia, 4(2), 68-71.

Chicago

J.W. ten Kate, Fiebo, G. Johan A. Offerhaus, Hugo Obertop, J. Jan B. van Lanschot, Johanna W. van Sandick,  and Wojciech Polkowski. 2000. "Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression". Contemporary Oncology/Współczesna Onkologia 4 (2): 68-71.

Harvard

J.W. ten Kate, F., Johan A. Offerhaus, G., Obertop, H., Jan B. van Lanschot, J., W. van Sandick, J.,  and Polkowski, W. (2000). Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression. Contemporary Oncology/Współczesna Onkologia, 4(2), pp.68-71.

MLA

J.W. ten Kate, Fiebo et al. "Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression." Contemporary Oncology/Współczesna Onkologia, vol. 4, no. 2, 2000, pp. 68-71.

Vancouver

J.W. ten Kate F, Johan A. Offerhaus G, Obertop H, Jan B. van Lanschot J, W. van Sandick J, Polkowski W. Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression. Contemporary Oncology/Współczesna Onkologia. 2000;4(2):68-71.

The aim of this study was to investigate the prognostic significance of the Laurén classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and/or gastro-esophageal junction (GEJ). Forty-one adenocarcinomas of the esophagus and/or GEJ were reviewed for tumor stage, Laurén classification, and c-erbB-2 by immunohistochemistry. According to the Laurén classification, tumors were classified as intestinal, mixed, or diffuse in 54%, 32%, and 15%, respectively. Diffuse tumors had a significantly worse prognosis than intestinal tumors. The prognostic value of the Laurén classification was independent of stage. C-erbB-2 overexpression was detected in 24% of the tumors and was present exclusively in intestinal tumors and in intestinal-type areas of mixed tumors. Ten of the 30 stage III/IV tumors were c-erbB-2 positive, while none of the 11 stage I/II tumors overexpressed the oncogene product.

Conclusions:

1) the Laurén classification is independent prognostic factor in adenocarcinoma of the esophagus and GEJ,

2) intestinal and diffuse tumors differ oncogenetically,

3) c-erbB-2 overexpression is associated with stage of disease.

keywords:

Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression

Fiebo J.W. ten Kate , G. Johan A. Offerhaus , Hugo Obertop , J. Jan B. van Lanschot , Johanna W. van Sandick , Wojciech Polkowski

Adenocarcinoma of the esophagus, Laurén classification, oncogenes, suergery, prognosis

Fiebo J.W. ten Kate

,

G. Johan A. Offerhaus

,

Hugo Obertop

,

J. Jan B. van Lanschot

,

Johanna W. van Sandick

,

Wojciech Polkowski