Prognostic impact of microsatellite instability in gastric cancer

Cesar Zepeda-Najar; Rodrigo Xavier Palacios-Astudillo; Jazmín Danaé Chávez-Hernández; Leonardo Saul Lino-Silva; Rosa A. Salcedo-Hernández

doi:10.5114/wo.2021.104939

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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abstract:

Short communication

Prognostic impact of microsatellite instability in gastric cancer

Cesar Zepeda-Najar

¹

,

Rodrigo Xavier Palacios-Astudillo

²

,

Jazmín Danaé Chávez-Hernández

²

,

Leonardo Saul Lino-Silva

²

,

Rosa A. Salcedo-Hernández

²

Surgical Oncology Division, Hospital Ángeles Tijuana, Mexico
Surgical Pathology, Instituto Nacional de Cancerología de México, Mexico

Contemp Oncol (Pozn) 2021; 25 (1): 68–71

DOI: https://doi.org/10.5114/wo.2021.104939

Online publish date: 2021/03/29

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Gastric cancer is a common and deadly cancer. Several factors are associated with its prognosis; however, controversy exists about the role of microsatellite instability (MSI). We aimed to determine the 5-year overall survival (OS) of MSI in gastric adenocarcinoma.

A cross-sectional study was carried out on gastric adenocarcinoma in clinical stages I to III treated with D2 gastrectomy between 2010–2013. MSI was demonstrated by immunohistochemistry. We performed a survival analysis comparing cases with and without MSI.

From 102 cases, 9.8% showed MSI. The median age was 63 years (range 33–91 years), and 57.8% were men. The more prevalent site of occurrence was the antrum (46.1%), 78.5% of the cases presented in stage III, 47.1% were of the diffuse type, 45.1% were of an intestinal type, and 7.8% were mixed. MSI cases were associated with lower clinical stages (stages I–II) and with better 5-year OS (100 vs. 47 months, p = 0.017). In a multivariate analysis, MSI was independently associated with better survival (HR = 0.209, 95% CI: 0.046–0.945, p = 0.042).

MSI gastric cancers presented in early clinical stages and had favourable prognosis compared with non-MSI cancers.

keywords:

Prognostic impact of microsatellite instability in gastric cancer

Cesar Zepeda-Najar 1 , Rodrigo Xavier Palacios-Astudillo 2 , Jazmín Danaé Chávez-Hernández 2 , Leonardo Saul Lino-Silva 2 , Rosa A. Salcedo-Hernández 2

gastric cancer, microsatellite instability, immunohistochemistry, cancer prognosis, overall survival

Cesar Zepeda-Najar

¹

,

Rodrigo Xavier Palacios-Astudillo

²

,

Jazmín Danaé Chávez-Hernández

²

,

Leonardo Saul Lino-Silva

²

,

Rosa A. Salcedo-Hernández

²