Prognostic significance of Bcl-2 gene protein family polymorphisms in patients with chronic lymphocytic leukaemia

Monika Joks; Krzysztof Lewandowski

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2008
vol. 12

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abstract:

Prognostic significance of Bcl-2 gene protein family polymorphisms in patients with chronic lymphocytic leukaemia

Monika Joks

,

Krzysztof Lewandowski

Współczesna Onkologia (2008) vol. 12; 4 (162-167)

Online publish date: 2008/07/22

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B-cell chronic lymphocytic leukaemia (B-CLL) is the most frequent type of leukaemia in the western hemisphere. It is an incurable disease, and is characterized by expansion of monoclonal malignant lymphoid B cells expressing on the surface CD 19, CD22, CD79b, CD23, CD5, CD20 low, CD5 , k/l (+) low. Leukaemic cells are present in the peripheral blood, bone marrow, and lymphoid tissues. In patients with B-CLL survival and time to progression are highly variable. Failed apoptosis plays an important role in pathogenesis of B-CLL. We present recent data concerning the role of Bcl-2 family proteins in regulation of apoptosis in B-CLL. We focus special attention on the BCL-2, BAX, MCL-1 genes polymorfphisms as potential novel prognostic risk factors in B-CLL patients.

keywords:

Prognostic significance of Bcl-2 gene protein family polymorphisms in patients with chronic lymphocytic leukaemia

Monika Joks , Krzysztof Lewandowski

chronic lymphotic leukemia, apoptosis, Bcl-2 family, single nucleotide polymorphisms

Monika Joks

,

Krzysztof Lewandowski