eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2023
vol. 74
 
Share:
Share:
abstract:
Original paper

Prognostic significance of a panel of two biomarkers (E-cadherin and CD105) in laryngeal cancer

Elvir Zvrko
1, 2
,
Ljiljana Vuckovic
2, 3
,
Miodrag Radunovic
2, 4

  1. Department of Otorhinolaryngology, Clinical Centre of Montenegro, Podgorica, Montenegro
  2. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
  3. Department of Pathology, Clinical Centre of Montenegro, Podgorica, Montenegro
  4. Department of Surgery, Clinical Centre of Montenegro, Podgorica, Montenegro
Pol J Pathol 2023; 74 (4): 225-231
Online publish date: 2024/01/17
View full text Get citation
 
PlumX metrics:
This study aimed to evaluate the clinicopathologic significance of the combined immunohistochemical expression of the epithelial-mesenchymal transition marker E-cadherin and the angiogenesis marker CD105 in laryngeal squamous cell carcinoma and assess correlation of their expression.

Eighty-five patients who underwent complete resection as primary treatment were selected for this study. E-cadherin and CD105 expression levels were determined by immunohistochemistry. The receiver operating curve approach was applied to determine the cut-off value and separate patients with high and low expression of markers.

The high-risk group (“CD105 high” and “E-cadherin low” expression) showed statistically significant correlations with age less than 66 years (p = 0.039), advanced T-status (T3–4) (p = 0.046), aggressive TNM stage (stage III–IV) (p = 0.003) and locoregional recurrence of disease (p = 0.004). In the Kaplan-Meier analyses, the high-risk group had significantly worse prognoses than other risk groups (log-rank test 2 = 9.415, p = 0.024).

Spearman’s correlation coefficient analysis showed a nonsignificant negative correlation between the expression of E-cadherin and CD105 (rho = –0.073, p = 0.505). Simultaneous consideration of E-cadherin and CD105 is a simple panel of markers to determine aggressive tumour phenotype with a higher risk of disease recurrence in patients with laryngeal cancer.
keywords:

E-cadherin, CD105, endoglin, larynx, cancer

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.