eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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3/2020
vol. 24
 
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abstract:
Original paper

Prognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancer

Ulaş Aday
1
,
Faruk Tatlı
2
,
Faik V. Akpulat
2
,
Mazlum İnan
2
,
Mehmet T. Kafadar
2
,
Hüseyin Bilge
2
,
Ömer Başol
2
,
Abdullah Oğuz
2

  1. Department of Gastrointestinal Surgery, Dicle University School of Medicine, Diyarbakır, Turkey
  2. Department of General Surgery, Dicle University School of Medicine, Diyarbakır, Turkey
Contemp Oncol (Pozn) 2020; 24 (3): 145–149
DOI: https://doi.org/10.5114/wo.2020.100219
Online publish date: 2020/10/30
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Introduction
To investigate the prognostic role of lactate dehydrogenase-to-albumin ratio (LAR) in gastric cancer patients undergoing curative resection.

Material and methods
A retrospective study was conducted including resectable gastric cancer patients. According to the time-dependent receiver operating characteristics (ROC) analysis, the optimal threshold for pretreatment LAR was 5.5. The Kaplan-Meier method, Cox regression univariate and multivariate analyses were used to analyze the prognostic factors for disease-free survival and overall survival (OS).

Results
The study cohort consisted of 81 patients, mean age was 60.2 ±13.8 (range, 29–87) years and 55 (67.9%) were male. The median OS time was 34.8 and 45 months in patients with LAR ≥ 5.5 (n = 50) and LAR < 5.5 (n = 31), respectively. Kaplan-Meier curves showed that with the increase in LAR there was reduced survival, but it was not statistically significant (p = 0.278). Multivariate analyses revealed that the positive lymph node ratio above 20% was an independent predictor in resectable gastric cancer patients (OR = 6.281, 95% CI: 1.135–34.767, p = 0.035).

Conclusions
With the increase in LAR survival in gastric cancer decreased, but it was not statistically significant. Studies involving a large patient series are needed.

keywords:

gastric cancer, curative surgery, LAR, survival
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