eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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1/2022
vol. 73
 
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abstract:
Original paper

Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer

Marzena Zalewska-Ziob
1
,
Brygida Adamek
2
,
Janusz Kasperczyk
3
,
Katarzyna Dobija-Kubica
4

  1. Chair and Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
  2. Department of Basic Medical Sciences, Faculty of Health Sciences in Bytom, Medical University of Silesia, Katowice, Poland
  3. Chair and Department of Environmental Medicine and Epidemiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
  4. John Paul II Hospital of Oncology, General Surgery Ward, Bielsko-Biala, Poland
Pol J Pathol 2022; 74 (1): 6-13
DOI: https://doi.org/10.5114/pjp.2022.117176
Online publish date: 2022/06/29
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Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti-

cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial

cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC.

In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.
keywords:

angiogenesis, non-small cell lung cancer, angiopoietin-1, five-year survival
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