Programmed death of leukocytes through Fas and TNFR1 in malnourished patients with pancreatic cancer

Sylwia Kędziora; Robert Słotwiński; Waldemar L. Olszewski; Marzanna Zaleska; Gustaw Lech; Maciej Słodkowski; Ireneusz W. Krasnodębski

doi:10.5114/pg.2011.20105

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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1/2011
vol. 6

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abstract:

Original paper

Programmed death of leukocytes through Fas and TNFR1 in malnourished patients with pancreatic cancer

Sylwia Kędziora

,

Robert Słotwiński

,

Waldemar L. Olszewski

,

Marzanna Zaleska

,

Gustaw Lech

,

Maciej Słodkowski

,

Ireneusz W. Krasnodębski

Przegląd Gastroenterologiczny 2011; 6 (1): 30–35

DOI: https://doi.org/10.5114/pg.2011.20105

Online publish date: 2011/03/01

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Aim : To evaluate the status of programmed leukocyte death (apoptosis) in malnourished pancreatic cancer patients in comparison with healthy controls.

Material and methods : The percentage of leukocytes with death receptors Fas (CD95) and TNFR1 (CD120a) was investigated in 72 pancreatic cancer patients in comparison with 30 healthy volunteers. Percentages of cells with receptors were assessed by flow cytometry.

Results : Results of the study show a significantly higher percentage of CD95+/CD3– cells and lymphocytes with TNFR1 in the group with pancreatic cancer in comparison with healthy controls.

Conclusions : Our studies show up-regulation of the pro-apoptotic signalling system in the leukocytes of patients with pancreatic cancer and a switch to apoptosis. These alterations may lead to leukocyte dysfunction and immune system suppression.

keywords:

Programmed death of leukocytes through Fas and TNFR1 in malnourished patients with pancreatic cancer

Sylwia Kędziora , Robert Słotwiński , Waldemar L. Olszewski , Marzanna Zaleska , Gustaw Lech , Maciej Słodkowski , Ireneusz W. Krasnodębski

pancreatic cancer, apoptosis, immune dysfunction

Sylwia Kędziora

,

Robert Słotwiński

,

Waldemar L. Olszewski

,

Marzanna Zaleska

,

Gustaw Lech

,

Maciej Słodkowski

,

Ireneusz W. Krasnodębski