Pseudoporphyria secondary to renal failure

Lilianna Kulczycka-Siennicka; Anna Woźniacka; Remigiusz Szumiński; Agnieszka Żebrowska

doi:10.5114/dr.2017.67386

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2017
vol. 104

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abstract:

Case report

Pseudoporphyria secondary to renal failure

Lilianna Kulczycka-Siennicka

,

Anna Woźniacka

,

Remigiusz Szumiński

,

Agnieszka Żebrowska

Dermatol Rev/Przegl Dermatol 2017, 104, 122–127

DOI: https://doi.org/10.5114/dr.2017.67386

Online publish date: 2017/04/28

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Introduction. Pseudoporphyria is a rare disease associated with chronic renal failure. Symptoms of pseudoporphyria may develop in response to UV exposure and medications. The literature reports cases of pseudoporphyria in patients infected with hepatis C virus, HIV and undergoing dialysis therapy.

Objective. Presentation of the case of a patient with pseudoporphyria and uraemic pruritus, and overview of therapeutic management.

Case report. A 64-year-old male patient, who had been on dialysis for chronic renal failure secondary to type 2 diabetes for the past 11 years, presented with tense bullae located on sun-exposed skin which had persisted for the previous 5 months. The patient was diagnosed with pseudoporphyria, and treatment was prescribed including N-acetylcysteine, chloroquine, paroxetine and mianserin. An improvement in the patient’s clinical condition and a regression of pruritus were achieved.

Conclusions. Patients with renal failure may develop symptoms of pseudoporphyria requiring differentiation from porphyria cutanea tarda.

keywords:

Pseudoporphyria secondary to renal failure

Lilianna Kulczycka-Siennicka , Anna Woźniacka , Remigiusz Szumiński , Agnieszka Żebrowska

dialysis therapy, pseudoporphyria, chloroquine, renal failure, porphyria cutanea tarda

Lilianna Kulczycka-Siennicka

,

Anna Woźniacka

,

Remigiusz Szumiński

,

Agnieszka Żebrowska