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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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5/2019
vol. 106
 
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abstract:
Case report

Pseudoscleroderma associated with POEMS syndrome

Kalina Wysocka-Dubielecka
1
,
Andrzej Bizoń
1
,
Katarzyna Głogowska
1
,
Dorota Mączyńska-Karcz
1
,
Katarzyna Łoza
1
,
Kazimierz Kalbarczyk
1
,
Oskar Janeczek
2
,
Marek Braszkiewicz
3

  1. Department of Adult Dermatology, Miedzyleski Specialist Hospital, Warsaw, Poland
  2. Department of Neurology, Miêdzyleski Specialist Hospital, Warsaw, Poland
  3. 1st Internal Department, Miêdzyleski Specialist Hospital, Warsaw, Poland
Dermatol Rev/Przegl Dermatol 2019, 106, 529-537
DOI: https://doi.org/10.5114/dr.2019.90001
Online publish date: 2019/12/06
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POEMS syndrome is a rare paraneoplastic disorder associated with plasma cell dyscrasia. The acronym stands for coexisting polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. Other relevant features of the syndrome are papilledema, sclerotic bone lesions, Castleman’s disease, thrombocytosis, weight loss and increased vascular endothelial growth factor levels. The diagnostic criteria for POEMS are as follows: major criteria: polyneuropathy, monoclonal plasma cell dyscrasia; minor criteria: sclerotic bone lesions, Castleman’s disease, organomegaly, endocrinopathies, edemas, skin changes, papilledema. To make a diagnosis, 2 major criteria and 1 minor criterion are required. We present a patient with pseudoscleroderma, polyneuropathy, hypothyroidism, monoclonal gammopathy, edemas and weight loss, who was diagnosed with POEMS syndrome as a result of interdisciplinary cooperation.
keywords:

hypothyroidism, polyneuropathy, monoclonal gammopathy, pseudoscleroderma, POEMS syndrome
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