Psoriasis in areas difficult to treat and biological therapy

Anna Lis-Święty; Aleksandra Frątczak

doi:10.5114/dr.2021.108615

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2021
vol. 108

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abstract:

Review paper

Psoriasis in areas difficult to treat and biological therapy

Anna Lis-Święty

¹

,

Aleksandra Frątczak

¹

Department of Dermatology, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland

Dermatol Rev/Przegl Dermatol 2021, 108, 171–177

DOI: https://doi.org/10.5114/dr.2021.108615

Online publish date: 2021/08/26

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Psoriasis often affects specific locations such as the nail apparatus, scalp, hands, feet, and genital areas. It usually coexists with severe plaque psoriasis. However in some cases only these areas may be affected, causing a significant deterioration of the patient’s quality of life, low self-esteem and depression. In the absence of effects of a topical treatment (glucocorticosteroids in monotherapy or combined with calcipotriol, keratolytic agents, phototherapy, calcineurin inhibitors) and standard systemic therapy (i.e., retinoids, methotrexate and cyclosporin), biological drugs are often used, even though the PASI score does not exceed 10. Interleukin-17 inhibitors and interleukin-23 inhibitors, are the most adequate biological drugs for isolated psoriasis in these special anatomic locations

keywords:

Psoriasis in areas difficult to treat and biological therapy

Anna Lis-Święty 1 , Aleksandra Frątczak 1

biological drugs, psoriasis, scalp, genitals, nails

Anna Lis-Święty

¹

,

Aleksandra Frątczak

¹