Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors

Juan Ignacio Arraras; Jose Juan Illarramendi; Ana Manterola; Uxue Zarandona; Berta Ibañez; Andrew Bottomley; Lucia Teijeira; Ignacio Visus; Susana de la Cruz; Marta Barrado; Ruth Vera

doi:10.5114/wo.2024.147006

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2024
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abstract:

Original paper

Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors

Juan Ignacio Arraras

^{1, 2, 3}

,

Jose Juan Illarramendi

^{1, 3}

,

Ana Manterola

^{2, 3}

,

Uxue Zarandona

^{2, 3}

,

Berta Ibañez

⁴

,

Andrew Bottomley

⁵

,

Lucia Teijeira

^{1, 3}

,

Ignacio Visus

^{2, 3}

,

Susana de la Cruz

^{1, 3}

,

Marta Barrado

^{2, 3}

,

Ruth Vera

^{1, 3}

Medical Oncology Department, Hospital Universitario de Navarra, Pamplona, Spain
Radiotherapeutic Oncology Department, Hospital Universitario de Navarra, Pamplona, Spain
Institute for Health Research of Navarre (IdiSNA), Pamplona, Spain
Methodology Unit, Navarrabiomed, RICAPPS, Spain
Bottomley Consulting Group, Brussels, Belgium

Contemp Oncol (Pozn) 2024; 28 (4): 350–357

DOI: https://doi.org/10.5114/wo.2024.147006

Online publish date: 2025/01/15

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AMA

Arraras J, Illarramendi J, Manterola A, et al. Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors. Contemporary Oncology/Współczesna Onkologia. 2024;28(4):350-357. doi:10.5114/wo.2024.147006.

APA

Arraras, J., Illarramendi, J., Manterola, A., Zarandona, U., Ibañez, B.,  & Bottomley, A. et al. (2024). Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors. Contemporary Oncology/Współczesna Onkologia, 28(4), 350-357. https://doi.org/10.5114/wo.2024.147006

Chicago

Arraras, Juan Ignacio, Jose Juan Illarramendi, Ana Manterola, Uxue Zarandona, Berta Ibañez, Andrew Bottomley,  and Lucia Teijeira et al. 2024. "Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors". Contemporary Oncology/Współczesna Onkologia 28 (4): 350-357. doi:10.5114/wo.2024.147006.

Harvard

Arraras, J., Illarramendi, J., Manterola, A., Zarandona, U., Ibañez, B., Bottomley, A., Teijeira, L., Visus, I., Cruz, S., Barrado, M.,  and Vera, R. (2024). Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors. Contemporary Oncology/Współczesna Onkologia, 28(4), pp.350-357. https://doi.org/10.5114/wo.2024.147006

MLA

Arraras, Juan Ignacio et al. "Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors." Contemporary Oncology/Współczesna Onkologia, vol. 28, no. 4, 2024, pp. 350-357. doi:10.5114/wo.2024.147006.

Vancouver

Arraras J, Illarramendi J, Manterola A, Zarandona U, Ibañez B, Bottomley A et al. Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors. Contemporary Oncology/Współczesna Onkologia. 2024;28(4):350-357. doi:10.5114/wo.2024.147006.

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Introduction:
Metastatic breast cancer (MBC) can profoundly impact patients’ lives. The health-related quality of life (HRQOL) of MBC metavivors remains a paramount concern. This study examined the multifaceted aspects of HRQOL in MBC metavivors.

Material and methods:
Ninety-eight participants with over 4 years of metastatic disease were evaluated using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires QLQ-C30, QLQ-BR42 and QLQ-BM22 alongside the Assessment of Survivor Concerns (ASC) questionnaire.

Results:
HRQOL scores were high (> 80/ 100 points) in some HRQOL areas, including role, cognitive and social functioning and breast symptoms. Moderate limitations (> 30 points) occurred in global QOL and financial impact (QLQ-C30); sexual functioning, sexual enjoyment, future perspective, breast satisfaction, upset by hair loss, skeletal symptoms, and weight gain (QLQ-BR42); and psychosocial aspects of QLQ-BM22. Worries were moderate in the two ASC factors (6.8 and 5.3) and the global scale (11.7). The multivariate model that best explains high risk of low global QOL included limiting comorbidity, financial impact, cancer worry and role functioning (R² = 0.692). Patients with only bone metastases showed higher cancer and health worries (ASC scale) than patients with soft tissues and visceral sites.

Conclusions:
This study shows that MBC metavivors adapted well to their situation and underscores the persistent HRQOL challenges they face. In-depth analysis of the QLQ-C30 global score highlights the need to address not only medical aspects but also integrated psychosocial and economical support in MBC metavivor care. HRQOL variations across metastatic sites underscore the need to tailor interventions to address site-specific challenges.

keywords:

Quality of life of patients treated for stage IV breast cancer. Multidimensional assessment and examination of determining factors

Juan Ignacio Arraras 1, 2, 3 , Jose Juan Illarramendi 1, 3 , Ana Manterola 2, 3 , Uxue Zarandona 2, 3 , Berta Ibañez 4 , Andrew Bottomley 5 , Lucia Teijeira 1, 3 , Ignacio Visus 2, 3 , Susana de la Cruz 1, 3 , Marta Barrado 2, 3 , Ruth Vera 1, 3

neoplasm metastasis, breast neoplasms, metavivors, quality of life