eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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4/2009
vol. 60
 
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Oncogenic osteomalacia associated with phosphaturic mesenchymal tumour, mixed connective tissue type of the knee

Anna Szumera-Ciećkiewicz
,
Konrad Ptaszyński
,
Andrzej Pawełas
,
Piotr Rutkowski

Pol J Pathol 2009; 4: 193-199
Online publish date: 2010/01/06
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One of the most unusual and uncommon types of osteomalacia is the oncogenic osteomalacia that is predominantly caused by a soft tissue or bone tumour, mostly by a phosphaturic mesenchymal tumour, mixed connective tissue type (PMTMCT). We report a case of a 27-year-old male presented with complaints of progressive and generalized muscle weakness, bone pains and multiple fractures. Intra-articular PMTMCT of the knee was diagnosed and surgically removed. We describe histopathological features of PMTMCT and review the most recent studies concerning this diagnostic problem.
keywords:

oncogenic osteomalacia, mesenchymal tumours, phosphaturia, fibroblast growth factor, FGF23
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