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ISSN: 0860-7796
BioTechnologia
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4/2011
vol. 92
 
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abstract:

RESEARCH PAPER
Selected aspects of endothelial dysfunction and their influence on the atherosclerosis process modeled and analyzed by Petri net based approach

Dorota Formanowicz
,
Adam Kozak
,
Piotr Formanowicz

BioTechnologia vol. 92(4) C pp. 359-368 C 2011
DOI: https://doi.org/10.5114/bta.2011.46553
Online publish date: 2014/10/28
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In this paper a Petri net based model of the process of endothelial dysfunction is presented. The model describes

some selected aspects of this process and their relation with atherosclerosis. Models expressed in the language

of Petri net theory have, on the one hand, an intuitive graphical interpretation, and on the other hand, they can

be analyzed using rigorous mathematical methods. Such analysis and simulation of the net behavior can be supported

by many freely available software tools. Here, results of an analysis based on t-invariants of the proposed

model are presented. In particular, feasible t-invariants, MCT-sets and t-clusters have been calculated and their

biological meaning has been determined.
keywords:

endothelial dysfunction, biological systems, modeling, Petri nets, t-invariants


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