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BioTechnologia
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3/2012
vol. 93
 
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RESEARCH PAPER
Sensitivity analysis of mathematical models of signaling pathways

Agata Charzyńska
,
Anna Nałęcz
,
Mikołaj Rybiński
,
Anna Gambin

BioTechnologia vol. 93(3) C pp. 291-308 C 2012
DOI: https://doi.org/10.5114/bta.2012.46584
Online publish date: 2014/10/29
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Modeling the dynamic behavior of signal transduction pathways is an important topic in systems biology. Mathematical

models complement experimental technologies used to identify the molecular components and interactions

in a system of interest. In this paper, we illustrate different types of mathematical approaches that are

used to model signaling network behavior. Here, we review the basic methods of sensitivity analysis and apply

them to the model of the system of membrane receptors. Four such receptors are considered: growth factor epidermal,

low density lipoprotein, transferrin and vitellogenin receptor. We argue that application of sensitivity analysis

methods provides an insight into how a signaling system controls the cell behavior.
keywords:

membrane receptors, ordinary differential equations, stochastic modeling, chemical master equation, sensitivity analysis


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