2/2011
vol. 92
abstract:
REVIEW PAPER An overall view of the process of the regulation
of human iron metabolism
BioTechnologia vol. 92(2) C pp. 193-207 C 2011
Online publish date: 2014/10/28
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Iron is a key component of many reactions in the human body, and by virtue of its ability to accept and donate
electrons, it is required for a variety of normal cellular functions and is vital for proper growth and development.
However, natural iron is rather insoluble and excess of iron is harmful since it can catalyze the formation of oxygen
radicals. Fortunately, there are also mechanisms for protecting human body from excess ‘free’ iron. This is
particularly important, given the fact that humans have very limited capacity to excrete iron. Therefore, cells have
developed mechanisms to improve the solubility of iron to control intracellular iron concentrations at the point
of iron absorption in the small intestine and other tissues. Since the described process is highly complex, a profound
understanding of all the relationships occurring among its components is possible when a systems approach
is applied to its analysis.
keywords:
iron, homeostasis, transferrin, hepcidin, formal models
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