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ISSN: 0860-7796
BioTechnologia
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4/2012
vol. 93
 
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abstract:

REVIEW PAPER
How to study G-quadruplex structures

Magdalena Małgowska
,
Dorota Gudanis
,
Anna Teubert
,
Grażyna Dominiak
,
Zofia Gdaniec

BioTechnologia vol. 93(4) C pp. 381-390 C 2012
DOI: https://doi.org/10.5114/bta.2012.46592
Online publish date: 2014/10/28
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All guanine-rich DNA and RNA molecules tend to fold into inter- and intra-molecular structures called G-quadruplexes.

The core of a G-quadruplex is composed of at least two adjacent G-tetrads stabilized by monovalent cations.

While it has been suggested that there could potentially be over 375 000 quadruplex forming sequences

in the human genome alone, only a small number of three-dimensional G-quadruplex structures are known. More

structural data are needed to explain their presence and function in vivo. We offer here a short review of experimental

methods commonly used to determine G-quadruplex topologies.
keywords:

G-quadruplex, UV spectroscopy, CD spectroscopy, mass spectrometry, NMR spectroscopy


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