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ISSN: 0860-7796
BioTechnologia
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4/2012
vol. 93
 
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abstract:

REVIEW PAPER
Non-nucleosidic analogs of nucleic acids

Jolanta Brzezińska
,
Katarzyna Adrych-Rożek
,
Zofia Jahnz-Wechmann
,
Jerzy Boryski
,
Wojciech T. Markiewicz

BioTechnologia vol. 93(4) C pp. 391-399 C 2012
DOI: https://doi.org/10.5114/bta.2012.46593
Online publish date: 2014/10/28
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This paper presents several analogs of nucleic acids, including their structure and selected physico-chemical properties,

reported recently as being obtained from non-nucleosidic units connected via phosphorodiester bonds.

These analogs are built from units that instead of sugar residues carry different diol structures functionalized

either with natural nucleobases or with other ring systems of an aromatic character. Some interesting nonnucleosidic

oligonucleotide analogs and their applications are described. Unlocked (UNA) and glycerol nucleic

acids (GNA) are also described.
keywords:

nucleic acids, oligonucleotides, non-nucleosidic nucleic acids, UNA, GNA, oligonucleotide analogs


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