eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
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4/2014
vol. 95
 
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abstract:
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RNA oligomers as microRNA production process regulators

Anna Kurzynska-Kokorniak
,
Natalia Koralewska
,
Agata Tyczewska
,
Tomasz Twardowski
,
Marek Figlerowicz

vol. 95(4) C pp. 272-275 C 2014
DOI: https://doi.org/10.5114/bta.2014.56600
Online publish date: 2015/12/21
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The present invention relates to an RNA oligomer, methods for regulating’a microRNA (miRNA) production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligomers disrupting a pre- iRNA structure as miRNA production process regulators. Oligomer interactions with a miRNA precursor (pre-miRNA) change the precursor’s secondary and tertiary structure. In consequence, the pre-miRNA is not specifically recognised and cleaved by the Dicer ribonuclease, and the specific miRNA is not produced


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