ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients

Edyta K. Glazewska; Marek Niczyporuk; Slawomir Lawicki; Maciej Szmitkowski; Monika Zajkowska; Magdalena Donejko; Andrzej Przylipiak

doi:10.5114/pdia.2017.66621

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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Original paper

ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients

Edyta K. Glazewska

,

Marek Niczyporuk

,

Slawomir Lawicki

,

Maciej Szmitkowski

,

Monika Zajkowska

,

Magdalena Donejko

,

Andrzej Przylipiak

Adv Dermatol Allergol 2018; XXXV (2): 167–173

DOI: https://doi.org/10.5114/pdia.2017.66621

Online publish date: 2018/04/24

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AMA

Glazewska E, Niczyporuk M, Lawicki S, et al. ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2018;35(2):167-173. doi:10.5114/pdia.2017.66621.

APA

Glazewska, E., Niczyporuk, M., Lawicki, S., Szmitkowski, M., Zajkowska, M.,  & Donejko, M. et al. (2018). ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 35(2), 167-173. https://doi.org/10.5114/pdia.2017.66621

Chicago

Glazewska, Edyta K., Marek Niczyporuk, Slawomir Lawicki, Maciej Szmitkowski, Monika Zajkowska, Magdalena Donejko,  and Andrzej Przylipiak. 2018. "ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 35 (2): 167-173. doi:10.5114/pdia.2017.66621.

Harvard

Glazewska, E., Niczyporuk, M., Lawicki, S., Szmitkowski, M., Zajkowska, M., Donejko, M.,  and Przylipiak, A. (2018). ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 35(2), pp.167-173. https://doi.org/10.5114/pdia.2017.66621

MLA

Glazewska, Edyta K. et al. "ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 35, no. 2, 2018, pp. 167-173. doi:10.5114/pdia.2017.66621.

Vancouver

Glazewska E, Niczyporuk M, Lawicki S, Szmitkowski M, Zajkowska M, Donejko M et al. ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2018;35(2):167-173. doi:10.5114/pdia.2017.66621.

Introduction
Psoriasis is a common, chronic inflammatory disease characterised by typical scaly skin lesions. The role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the pathogenesis and development of this condition have been repeatedly emphasised in available literature.

Aim
ROC analysis of selected MMPs (MMP-2, MMP-3, MMP-9, MMP-12, TIMP-2) and TIMPs (TIMP-2, TIMP-3) in psoriasis patients. The area under the ROC curve (AUC) indicates the clinical usefulness of a biomarker and its diagnostic power.

Material and methods
Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMPs and TIMPs were determined using the enzyme-linked immunosorbent assay (ELISA) while Psoriasis Area and Severity Index (PASI) was used to define disease advancement.

Results
In the total psoriasis patients group, the largest area under the ROC curve was obtained for TIMP-3. After the division of the total group based on disease severity, the highest AUC of all tested parameters was observed for patients with mild disease severity and subgroup Ia for TIMP-3, for subgroup Ib for MMP-12, and for individuals with moderate disease severity for MMP-2. The combined analysis of all tested parameters showed an increase in AUC values in the total group examined as well as in all groups of disease severity.

Conclusions
These results indicate the usefulness and high diagnostic power of TIMP-3 in early detection of psoriasis. Additionally, the combination of all tested parameters appeared to be a valuable biomarker panel for the analysed disease.

keywords:

ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients

Edyta K. Glazewska , Marek Niczyporuk , Slawomir Lawicki , Maciej Szmitkowski , Monika Zajkowska , Magdalena Donejko , Andrzej Przylipiak

MMP-2, MMP-3, MMP-9, MMP-12, TIMP-2, TIMP-3

Edyta K. Glazewska

,

Marek Niczyporuk

,

Slawomir Lawicki

,

Maciej Szmitkowski

,

Monika Zajkowska

,

Magdalena Donejko

,

Andrzej Przylipiak