Rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions

Martyna Skręta-Śliwińska; Anna Woźniacka; Ilona Kurnatowska; Maciej Goździk; Agnieszka Żebrowska

doi:10.5114/dr.2019.86911

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2019
vol. 106

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abstract:

Case report

Rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions

Martyna Skręta-Śliwińska

¹

,

Anna Woźniacka

¹

,

Ilona Kurnatowska

^{2, 3}

,

Maciej Goździk

^{2, 3}

,

Agnieszka Żebrowska

¹

Department of Dermatology and Venereology, Medical University of Lodz, Poland/Klinika Dermatologii i Wenerologii Uniwersytetu Medycznego w Łodzi, Polska
Department of Clinical Pharmacology, 1st Department of Internal Medicine, Medical University of Lodz, Poland/Zakład Farmakologii Klinicznej I Katedry Chorób Wewnętrznych Uniwersytetu Medycznego w Łodzi, Polska
Department of Nephrology, N. Barlickiego University Hospital in Lodz, Poland/Oddział Nefrologii Uniwersyteckiego Szpitala Klinicznego im. N. Barlickiego w Łodzi, Polska

Dermatol Rev/Przegl Dermatol 2019, 106, 291–301

DOI: https://doi.org/10.5114/dr.2019.86911

Online publish date: 2019/08/24

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Introduction
Systemic lupus erythematosus is a multi-organ connective tissue disease of heterogeneous clinical presentation.

Objective
This article presents a case of a fulminant disease in a woman in which acute cutaneous lesions preceded multi-organ dysfunction, including acute kidney injury.

Case Report
Papular eruptions demonstrating a tendency to exudate and formation of erosions appeared on the patient’s facial skin. Erosions were present on oral mucosa, and maculopapular lesions developed on thighs. Lesions were accompanied by high fever, general malaise and pain of muscles and joints. Haematological and immunological abnormalities as well as a decrease in kidney function were observed. A rapid development of systemic lupus erythematosus was diagnosed an the treatment with glucocorticosteroids, cyclophosphamide, plasmapheresis and haemodialysis was introduced, resulting in remission.

Conclusions
Acute onset of systemic lupus erythematosus often imitates an infectious disease. Presence of cutaneous lesions typical for systemic lupus erythematosus allows early diagnosis and introduction of appropriate treatment.

keywords:

Rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions

Martyna Skręta-Śliwińska 1 , Anna Woźniacka 1 , Ilona Kurnatowska 2, 3 , Maciej Goździk 2, 3 , Agnieszka Żebrowska 1

systemic lupus erythematosus, acute kidney injury, serositis, plasmapheresis

Martyna Skręta-Śliwińska

¹

,

Anna Woźniacka

¹

,

Ilona Kurnatowska

^{2, 3}

,

Maciej Goździk

^{2, 3}

,

Agnieszka Żebrowska

¹