Ratio of cord blood bilirubin and albumin as predictors of neonatal hyperbilirubinaemia

Indra Sharma; Dinesh Kumar; Astitva Singh; Tariq Mahmood

doi:10.5114/ceh.2020.102170

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Ratio of cord blood bilirubin and albumin as predictors of neonatal hyperbilirubinaemia

Indra Kumar Sharma

¹

,

Dinesh Kumar

¹

,

Astitva Singh

¹

,

Tariq Mahmood

²

Uttar Pradesh University of Medical Sciences, India
SRMS IMS, Bhojpura, Bareilly, Uttar Pradesh, India

Clin Exp HEPATOL 2020; 6, 4: 384–388

DOI: https://doi.org/10.5114/ceh.2020.102170

Online publish date: 2020/12/30

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Introduction
To compare cord blood albumin (CBA) and cord blood bilirubin (CBB) at birth as predictors for development of neonatal hyperbilirubinaemia.

Material and methods
CBA and CBB of 388 healthy term neonates born by lower segment caesarean section (LSCS) were determined at birth and transcutaneous bilirubin (TCB) was measured every 12 hours from birth until 7 days of life or development of hyperbilirubinaemia requiring phototherapy.

Results
The cut-off value of CBB and CBA as obtained by the receiver operating characteristic (ROC) curve was 1.90 mg/dl and 3.17 g/dl respectively. The sensitivity, specificity and positive predictive value (PPV) for CBB were 97.4%, 40.6% and 71.09% while for CBA they were 40.8%, 34.8% and 48.41%. The cut-off value for CBB/CBA ratio was 0.719 as obtained by the ROC curve and was determined to have 97.4% sensitivity, 62.6% specificity and a PPV of 79.61%.

Conclusions
CBB/CBA is a better indicator compared to CBA and CBB alone for prediction of neonatal hyperbilirubinaemia

keywords:

Ratio of cord blood bilirubin and albumin as predictors of neonatal hyperbilirubinaemia

Indra Kumar Sharma 1 , Dinesh Kumar 1 , Astitva Singh 1 , Tariq Mahmood 2

cord blood albumin, neonatal hyperbilirubinaemia, phototherapy, sensitivity

Indra Kumar Sharma

¹

,

Dinesh Kumar

¹

,

Astitva Singh

¹

,

Tariq Mahmood

²