eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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4/2007
vol. 6
 
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abstract:

Reactive oxygen species generation in women with osteoporosis

Tomasz Stetkiewicz
,
Marcin Makowski
,
Grzegorz Stachowiak
,
Ireneusz Połać
,
Grzegorz Surkont
,
Tomasz Pertyński

Przegląd Menopauzalny 2007; 4: 239–243
Online publish date: 2007/08/28
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Reactive oxygen species generation seems to be one of the important factors in osteoporosis pathogenesis. Aim of study: Comparison of reactive oxygen species (ROS) generation by neutrophils of peripheral blood in postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD). Material and methods: 76 postmenopausal women were included in the study. Based on spinal densitometry three groups of women were selected: group I with normal BMD (n=22), group II with osteopenia (n=28) and group III with osteoporosis (n=26). Reactive oxygen species generation by neutrophils of peripheral blood was evaluated using chemiluminescence measurement. Results: Areas under curves and maximal energy values of spontaneous chemiluminescence and stimulated neutrophils show no differences between the mentioned groups. Conclusions: ROS generation by neutrophils in blood of postmenopausal women with osteoporosis and osteopenia do not differ from parameters of this phenomenon in patients with normal BMD.
keywords:

osteoporosis, osteopenia, reactive oxygen species
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