![](/f/f/edb99351d8b637542eaefa34ca48e89b.jpg)
Current issue
Archive
Manuscripts accepted
About the journal
Editorial board
Abstracting and indexing
Contact
Instructions for authors
Ethical standards and procedures
Editorial System
Submit your Manuscript
|
3/2022
vol. 97 Special paper
Recommendations of the Polish Society of Gynaecologists and Obstetricians, Polish Paediatric Society, Polish Society of Family Medicine, Polish Society of Vaccinology, Polish Society of Oncological Gynaecology, and Polish Society of Colposcopy and Pathophysiology of the Uterine Cervix on prophylactic vaccinations against infections with human papillomaviruses in Poland
Andrzej Nowakowski
1, 2
,
Robert Jach
3
,
Leszek Szenborn
4
,
Mariusz Bidziński
5, 6
,
Teresa Jackowska
7
,
Jan Kotarski
8
,
Agnieszka Mastalerz-Migas
9
,
Aneta Nitsch-Osuch
10
,
Jarosław Pinkas
11
,
Włodzimierz Sawicki
12
,
Piotr Sieroszewski
13
,
Maciej Stukan
14, 15
,
Jacek Wysocki
16
Pediatr Pol 2022; 97 (3): 167-175
Online publish date: 2022/10/18
Article file
- Recommendations.pdf
[0.17 MB]
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
HUMAN PAPILLOMAVIRUSES AS AN AETIOLOGICAL FACTOR OF DISEASESHuman papillomavirus (HPV) infections are one of the most common genital organ infections in humans, mostly asymptomatic and spontaneously regressing. However, in a few to a dozen or so percent of those infected, lesions develop in various anatomical locations. It is estimated that HPV is responsible for the development of nearly 100% of precancerous lesions and cervical cancers, approximately 64–100% of precancerous conditions and vaginal cancers, 90% of anal cancers, 30% of penile cancers, and 15–30% of vulvar cancers [1–3]. HPV also causes some cases of head and neck cancers (oral cavity – approx. 3.7%; nasopharynx – approx. 11%; base of tongue, tonsil – approx. 19.9%; unspecified part of the throat – approx. 25%) [2, 3]. HPV is the aetiological factor of genital warts and recurrent laryngeal papillomatosis. So far, around 200 HPV genotypes have been classified, of which currently 14 (designated as: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) are considered high-risk genotypes of neoplastic lesions. The so-called low-risk genotypes 6 and 11 are responsible for the development of most genital warts and recurrent laryngeal papillomatosis. The infection frequency, carrier status, and distribution of HPV genotypes varies depending on the anatomical location of the infection, sex, age, and geographic region and population. About 70% of cervical cancers in the world are caused by HPV 16 and 18 [4], and genotype 16 dominates in all HPV- dependent neoplasms [1]. In Polish material, it was estimated that genotypes 16 and 18 are responsible for the development of approx. 83% of HPV-DNA positive cervical cancers, and approx. 85% of high-grade intraepithelial lesions (direct precancers) are aetiologically associated with HPV 16, 33, 31, 52, 45, and 58 [5]. It is estimated that 690 thousand cases of cancer globally in 2020 [6] and about 3 thousand in Poland in 2015 [2] were associated with HPV infections. Cervical cancer is by far the biggest problem for public health in Poland among the diseases aetiologically related to HPV due to the highest incidence and the threat to the health and life of young women. There are no official registers in Poland, but by extrapolating world data [7], the incidence of genital warts and recurrent laryngeal papillomatosis can be estimated at several dozen thousand and several hundred cases per year, respectively.PROPHYLACTIC HPV VACCINESCurrently, 3 vaccines are registered in most countries of the world and in Poland. All of them contain virus-like particles (VLPs) made of purified protein of the main viral capsid L1, produced by recombinant DNA technology, and adjuvants. Vaccines do not contain live viruses or their DNA material. Vaccines cannot cause infection, and the non-infectious VLPs included in vaccines are not replicative. The mechanism of action of HPV vaccines is based on induction of a humoral immune response and the presence of neutralizing antibodies and their activity at the site of infection. Antibody concentrations obtained after vaccination decrease with the time interval after vaccination and then remain at a stable level, many times higher than those recorded after natural infection, for many years [8]. Prophylactic HPV vaccines do not have therapeutic properties, and do not change the course of the ongoing infection or the clinical course of lesions caused by the virus. Therefore, to obtain the immunity of individual people and the maximum population effect, they should be given to individuals before contact with the virus, i.e. before sexual debut. From a meta-analysis of data covering 60 million vaccinated people over a period of 8 years of follow-up, the highest effectiveness in the prevention of high-grade precancerous conditions of the cervix and genital warts was demonstrated in the group of girls vaccinated up to 19 years of age (lower, but also significant in women up to 29 years of age) [9]. A summary of the approved vaccines is presented in Table 1.SAFETYVaccination safety is a key aspect of ensuring an appropriate balance of benefits against the potential risks of this form of prophylaxis in populations of young, healthy people. All 3 HPV vaccines have undergone appropriate pre-approval studies, have passed regulatory agencies’ positive assessment of their safety, and are subject to ongoing post-approval surveillance (bivalent – HPV 2 and quadrivalent – HPV 4 vaccines for over 15 years, and nine-valent – HPV 9 for 9 years). Post-vaccine adverse reactions (VARs) observed in clinical trials with all 3 vaccines were similar in profile and incidence. For HPV 4, the most common local post-vaccination symptoms were pain (84%), erythema (< 25%), and swelling (25%) at the injection site, with pain more frequent than with placebo (saline – 49%; placebo containing aluminium – 75%). These symptoms occurred more frequently after the use of HPV 2 and HPV 9 [7]. Transient low-grade fever/fever is the only systemic adverse reaction that occurs more frequently (> 10%) in individuals vaccinated with HPV vaccines than in people vaccinated with placebo [7]. Common but rapidly reversing VARs after HPV vaccinations include headache and dizziness (> 10%), muscle and joint pain, abdominal pain, nausea, and vomiting (frequency 1 – 10%). The HPV vaccines, as with other vaccines administered to adolescents, have also been associated with syncope, which is classified as a psychogenic needle-stick reaction. Anaphylaxis after HPV vaccinations occurs with a similar frequency as after administration of other vaccines. Data on the safety of HPV vaccinations have been collected in people from 9 years of age and are still collected and analysed, as in the case of other preventive vaccines [10].In post-registration reports, a cause-and-effect relationship was suggested between HPV vaccinations and the occurrence of Guillain-Barré syndrome, complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), premature ovarian insufficiency (POI), autoimmune diseases, and others. Due to these reports and the related media controversy, HPV vaccines are among the most thoroughly examined and constantly monitored in terms of safety. So far, none of the suspicions has been confirmed in analyses carried out on large vaccinated populations [11–13]. However, they remain the subject of further observations and debates [14–16]. In the HPV 4 safety analysis including data from clinical trials and databases, in the 9-year post-marketing period, only syncope and local skin reactions were associated with vaccinations [17]. Compared to HPV 4, local VARs were more frequent after HPV 9, but the incidence of serious VARs was the same [19]. Vaccination against HPV is not recommended in pregnant women; however, no differences in the incidence of complications during pregnancy were found in vaccinated and unvaccinated women during pregnancy [18-20]. IMMUNOGENICITYThe immunogenicity of HPV vaccines has been assessed in many clinical trials. Bridging studies of antibody levels formed the basis of vaccination registration in adolescents (in whom efficacy studies could not be conducted) and a 2-dose vaccination schedule (antibody titres not lower than after the 3-dose schedule) in young people [8]. The percentage of people with seroconversion after receiving the full vaccination course significantly exceeds 90%, and the achieved titres of neutralizing antibodies are many times higher than those observed after natural infection [8]. The highest titres are recorded 4 weeks after the last dose, then antibody concentrations reach a plateau significantly exceeding those after natural infection [21]. The duration of post-vaccination protection is predicted for several dozen years [21]. The minimum protective level of antibodies against infection and the need for and timing of a booster dose have not yet been established.EFFECTIVENESSThe effectiveness of vaccines assessed in clinical trials depended on many factors, such as: current or past HPV infection, age and sex of the vaccinated person, end point (type, severity, anatomical location of the lesion caused by HPV infection), and the follow-up period after vaccination [22–25]. The highest (up to 100%) efficacy was observed in the prevention of advanced precancerous lesions caused by vaccine HPV genotypes in people without indicators of current and previous infection [22, 26, 27]. For HPV 4, the efficacy against high-grade intraepithelial lesions of the cervix (CIN2+), vagina/vulva (VaIN2+/VIN2+) caused by vaccine types 6, 11, 16, and 18 was assessed in a combined analysis of 3 phase II/III clinical trials at 98.2% (95% CI: 93.3–99.8%) and 100% (95% CI: 82.6–100%), respectively, in HPV-DNA and seronegative women for vaccine types [22]. In the cohort of women with no previous/current infection markers, the effectiveness of HPV 2 in preventing HPV 16/18-dependent lesions of CIN3+ and CIN2+ was 100% (95% CI: 85.5–100.0%) [23] and 89.8% (95% CI: 39.5–99.5%), respectively [24]. The efficacy of HPV 2 in preventing CIN3+ caused by all HPV genotypes (also not included in the vaccine) was 93.2% (95% CI: 78.9–98.7) [23] in previously uninfected women. High effectiveness of HPV 9 in the prevention of diseases caused by HPV 31, 33, 45, 52, and 58 was demonstrated in comparative studies with HPV 4 [18]. The effectiveness of HPV 4 in the prevention of HPV 6/11/16/18-dependent lesions of the external genitalia in young men with no previous indicators of infection was estimated at 90.4% (95% CI: 69.2–98.1) [25], and the effectiveness in the prevention of advanced precancerous anal lesions reached 74.9% (95% CI: 8.8–95.4). The effectiveness of HPV 2 in the prevention of HPV 16/18, HPV 31/45, and HPV 31/33/45 infections in the oropharyngeal cavity reached 82.4% (95% CI: 47.3–94.1), 75.3 % (95% CI: 12.7–93.0), and 69.9% (95% CI: 29.6–87.1), respectively [28].POPULATION EFFECTSHigh effectiveness of HPV vaccines in clinical trials in reducing the incidence of HPV infections and their clinical manifestations has an impact on the reduction of the incidence of HPV-related infections and diseases, which has been demonstrated not only in models [29] but also in meta-analyses of population studies [9]. Recently published English data show a reduction in the risk of invasive cervical cancer and CIN3 by 87% (95% CI: 72–94) and 97% (95% CI: 96–98), respectively, in vaccinated girls aged 12-13 years [30]. An almost 90% reduction in the incidence of cervical cancer has also recently been reported among Swedish girls vaccinated before the age of 17 years [31]. In Denmark, after the implementation of the population-based, free-of-charge HPV vaccination programme, a significant decrease in the incidence of cervical cancer was noted, especially in the populations that received vaccines before the age of 16 [32]. The effectiveness of HPV 4 in the prevention of genital warts at the population level was estimated at 74% (95% CI: 68–79) in the Valencia region [33]. Eight years after the introduction of population-based HPV vaccination in Australia, a reduction in the incidence of preterm labour (3.2%; 95% CI: 1.1–5.3%) and low birth weight new-borns (9.8%; 95% CI: 8.2–11.4%) was noticed, which may be associated with a reduction in the frequency of cervical excisional procedures in young women [34]. After the implementation of the population-based, free-of-charge HPV vaccination before the age of 16 years, the risk of developing high-grade intraepithelial neoplasia of the vagina and vulva, respectively, was reduced by 85% and 78%, in an analysis of over 500,000 patients [35]. Demonstration of the effectiveness of HPV vaccines in reducing the incidence of less common HPV-dependent cancers such as head and neck, vulva, and vagina, and other pathological lesions such as recurrent laryngeal papillomatosis will require longer observations and large cohorts of subjects. So far, an almost 90% reduction in HPV 16/18/6/11 infections in the oral cavity has been demonstrated in vaccinated versus unvaccinated young Americans [36].VACCINATION AGAINST HPV IN SPECIAL COHORTS AND CLINICAL SITUATIONSImmunodeficiency, e.g. in the course of HIV infections and the use of immunosuppressants, is the strongest known risk factor for the acquisition, persistance, and progression of HPV infections to lesions (precancerous conditions, neoplasms, papillary lesions) [37, 38]. It therefore seems that immunodeficient individuals may benefit from HPV vaccination, although there are no results of large, prospective studies in this area. Although prophylactic vaccines have no therapeutic effect, there is a body of evidence showing a lower rate of recurrence of precancerous cervical lesions after treatment in HPV vaccinated than in unvaccinated women [39–41]. The observations of some of the authors of this position show that Polish women diagnosed and treated due to cervical precancerous conditions are a group willing to undergo HPV vaccinations. These women very often ask their gynaecologists about the possibility of vaccinating their children. Partial reimbursement gives additional opportunities to make use of the vaccination potential in this group of patients.RECOMMENDATIONS OF OTHER ORGANIZATIONS AND SOCIETIESDue to favourable data from clinical trials regarding the immunogenicity, effectiveness, and safety of HPV vaccinations and the registration of the first vaccine in 2006, starting from 2007, HPV vaccinations were recommended by influential societies and organizations, and they began to be implemented in immunization programmes in a number of countries in world. So far, Poland has not joined the group of nearly 90% of high-income countries according to the World Bank classification, which have implemented HPV vaccination in PIPs [42]. The Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem announced by the WHO in 2020, among its 3 key goals, included one to fully vaccinate 90% of the population of girls up to 15 years of age by the year 2030 [42]. The key points of the previous WHO position from 2017 are as follows: 1) HPV vaccinations should be implemented in national immunization programmes, 2) the prevention of cervical cancer is a priority, 3) HPV vaccinations should be carried out in girls prior to sexual initiation, 4) vaccination should be implemented as part of a coordinated strategy including, inter alia, education on the risk of HPV infections, training of medical personnel, and information for women on screening tests, 5) the priority cohort for vaccination is girls between 9 and 14 years of age, and 6) vaccination of secondary target groups (girls > 15 years of age and boys) is only recommended if it is feasible, cost effective, and does not limit the funding of priority cohort vaccinations and cervical cancer screening programmes [7]. The position of the European Centre for Disease Prevention and Control from 2020 is mainly devoted to the vaccination of people with HIV, boys, and the introduction of HPV 9 [43]. Among the key conclusions, it points to: 1) the effectiveness of HPV 9 in the prevention of infections and lesions related to HPV 31, 33, 45, 52, and 58 (high quality data) and HPV 6, 11, 16, and 18 (indirect data, moderate quality), 2) no direct data on the effectiveness of HPV 2 in men (evidence of its high immunogenicity), 3) high dependence of cost-effectiveness on priorities and the local situation in a given country (if the priority is cervical cancer prevention, the most cost-effective strategy is to maximize vaccination of girls; vaccination of boys may improve effectiveness cost-effective with a low coverage of the cohorts of girls; universal vaccination of girls and boys is recommended if the goal is to prevent various consequences of HPV infections). The United States Advisory Committee on Immunization Practices: 1) recommends routine immunization of 11–12-year-olds and catch-up vaccinations for unvaccinated people up to 26 years of age, 2) points to minimal public health benefits of vaccinating people between 26 and 45 years of age, and 3) recommends taking combined (doctor-patient) decisions in this regard because these individuals may benefit from vaccination in individual situations [44]. The National Oncological Strategy for 2020-2030 in Poland assumes the commencement of the vaccination process for girls and boys in 2021 and 2026, respectively, and vaccinating at least 60% of adolescents by 2028, and also points to the need to conduct an information campaign on the benefits of HPV vaccination [45]. HPV vaccines have the recommendation of the President of the Agency for Health Technology Assessment and Tariff System [46, 47], and according to the opinion of experts from 2020, they should constitute an integral part of the comprehensive prevention of cervical cancer in Poland [48].POLISH RECOMMENDATIONS FOR VACCINATION AGAINST HPVPrevious positions of Polish scientific societies on HPV vaccination are over 10 years old. They emphasized that prophylactic vaccinations should be a practice complementary to regular cytological screening [49]. The important role of paediatricians and family doctors in education about and primary prevention of cervical cancer in Poland was also indicated [50].LOCAL GOVERNMENT HPV VACCINATION PROGRAMmeS IN POLAND AND THEIR EXPERIENCESVaccinations against HPV in the years 2010–2017 were the most frequently implemented local government prevention programmes with a positive opinion from the Agency for Health Technology Assessment (currently the Agency for Health Technology Assessment and Tariff System). However, the overall vaccination coverage of the target female population was very low, ranging from just 1% to 1.5% between 2015 and 2017. The highest number of vaccinations in this period was carried out in the Dolnośląskie, Pomorskie, Śląskie, Wielkopolskie, and Mazowieckie voivodships (63% of all vaccinations in Poland). In 2017, HPV vaccines were reimbursed by 223 local governments, including 9 also for boys. During the 10 years of operation of local government programmes, approximately 180,000 girls were vaccinated. Immunization coverage depended on the region of Poland – higher in the west than in the east of the country – on average about 55% of the eligible individuals [51]. In 12 editions of the Wrocław HPV vaccination programme, in 2010–2021, on average 75.2% of 13-year-old female students (n = 16,301) were vaccinated. The schoolgirls were vaccinated in district clinics. Every year, the implementation of the programme was accompanied by comprehensive educational activities aimed at parents, students of both sexes, teachers, and doctors and nurses from vaccination centres. A total of 28,632 parents (60% on average) and 33,949 students (70% on average) participated in educational meetings. In the first 5 years, the average vaccination coverage was 83% [52]. During the peak period of media anti-vaccination propaganda and the broadcast of the film “Vaxxed” in the 2016/17 and 2017/18 editions of the programme, the percentage of vaccinated people fell to the critical level of 62%. Studies among parents, students, and vaccinating nurses were executed. It was shown that nurses participating in the programme were not sufficiently aware of their role in building acceptance of immunization. Among the determinants of doubts regarding vaccination against HPV among the inhabitants of Wrocław, the fear of side effects of vaccinations and a lack of trust in the effectiveness of vaccination were identified. Contrary to the results of studies on doubts regarding HPV vaccination from other countries, the respondents from Wrocław did not report any concerns related to the alleged promotion of promiscuity as a result of vaccination [53]. Changes in educational programmes were introduced, which were extended with elements of training in the field of communication skills with the patient, and the monitoring of doubts concerning HPV vaccination was intensified. These changes resulted in a renewed increase in vaccination coverage to a satisfactory level of 70% [54]. Similar conclusions can be drawn from vaccination programmes in Europe and the USA. The highest vaccination rates in the target population were achieved through organized school vaccinations [55], combined with consistent medical recommendations and public education [56, 57].RECOMMENDATIONS FOR POLAND1. Prophylactic HPV vaccinations should be an integral part of the comprehensive cervical cancer prevention in Poland. HPV vaccines enable the reduction of the incidence of other diseases aetiologically related to HPV infections.2. The priority target group for HPV vaccination are girls aged 11-13 years. 3. As the next step, girls over 13 years of age and boys 11–13 years of age should be vaccinated. 4. We should strive for the fastest possible implementation of free-of-charge HPV vaccinations of adolescents aged 11–13 years in the Preventive Immunization Programme. 5. Population-based vaccinations against HPV should ultimately be implemented within the framework of existing, proven, organizational solutions in the Preventive Immunization Programme to cover the target cohorts as widely as possible. 6. The qualification for HPV vaccination does not differ from other vaccinations. According to the general recommendations, the only permanent, absolute contraindication to further vaccination, including HPV, is an anaphylactic reaction that occurred after the previous dose of the vaccine or administration of any of its components. Mild or moderate reactions following the administration of the previous dose of the vaccine, such as pain, redness and swelling at the injection site, and slight or moderate fever after the previous dose of the vaccine, are not a contraindication for vaccination. There is no need to conduct a pregnancy test before administration. The use of hormonal contraceptives has no effect on the immune response. Temporary/relative contraindications include: moderate or severe acute illness, whether with or without fever, e.g. streptococcal angina, influenza, acute bronchitis, or acute diarrhoea. Moreover, the exacerbation of the chronic disease process is a relatively temporary contraindication. In these cases, vaccination is postponed until the acute symptoms subside, and in chronic diseases until remission is achieved and the patient’s condition is stabilized. 7. HPV vaccines can be administered concurrently or at any intervals with other vaccines, but in a different site – e.g. the opposite arm, or with a minimum distance of 2.5 cm from the site of the first vaccine injection. The safety of concurrent administration of HPV vaccines with pertussis, diphtheria, tetanus, inactivated polio vaccines, hepatitis A and B vaccines, Meningococcal, and COVID-19 has been tested and demonstrated. As part of the vaccination campaign of whole groups of adolescents, VARs may develop in the form of fainting, which in this case is triggered by pain or anxiety. People who pass out can fall and injure themselves if they do not sit or lie down. Giving patients a drink, a snack, ensuring the safety of the procedure, and vaccinating while lying or sitting has been shown to prevent syncope associated with the vaccination procedure. In addition, patients should be observed for 30 minutes after vaccination. If a patient faints after vaccination, he or she should be monitored by a healthcare professional until he/she regains consciousness (usually within a few minutes), so that the need for any further medical treatment can be determined. 8. To achieve optimal population effects, if it is necessary to select one product for vaccination under the Preventive Immunisation Programme, the selection of the vaccine should be made on the basis of an independent pharmaco-economic analysis taking into account, inter alia, data from clinical trials in terms of efficacy against key endpoints, vaccine price achieved in a tender/auction, and the distribution of HPV genotypes in lesions in Poland. 9. People older than planned for the free-of-charge immunization in the Preventive Immunisation Programme may also benefit from HPV immunization and should be vaccinated in line with the prescribing information for all 3 approved vaccines. 10. HPV vaccination should be recommended to women diagnosed and treated for precancerous conditions of the cervix because they may benefit from a lower risk of recurrence of lesions. 11. An extremely important element of the implementation of HPV vaccines are educational activities in target populations for vaccinations and their guardians, for medical personnel, and the entire society, which should be conducted centrally (media campaigns, etc.), regionally/locally (scientific and educational conferences, educational and information activities of producers, etc.), and individually (in clinics and offices) in order to provide maximum information about the benefits of HPV vaccination. Frequently asked questions and answers on vaccination against HPV will be published on the website of the Polish Society of Family Medicine. DISCLOSUREDeclaration of potential conflicts of interest: A.N. – advisory board, lectures, scientific report writing (GSK); R.J. – grant (GSK), opinion on Cervarix for the Agency of Health Technology Assessment and Tariff in Poland; L.S. – lectures and execution of clinical trials (GSK, MSD); M.B. – no conflict of interest; T.J. – no conflict of interest; J.K. – no conflict of interest; A.M.M. – advisory board (MSD); A.N.-O. – advisory board, lectures (GSK, MSD); J.P. – no conflict of interest; W.S. – no conflict of interest; P.S. – no conflict of interest; M.S. – lectures (MSD); J.W. – execution of clinical trials with HPV vaccines, advisory board (GSK, Pfizer, MSD).Due to the interdisciplinary scope of these recommendations and to reach the largest possible audience, this manuscript was simultaneously submitted for publication in the following journals: "Ginekologia Polska", "Ginekologia i Perinatologia Praktyczna", "Lekarz POZ", "Family Medicine & Primary Care Review", "Onkologia po Dyplomie", "Pediatria Polska", Przegląd Pediatryczny". REFERENCES1. https://hpvcentre.net/ (Accessed: 20.10.2021). 2.
https://www.mp.pl/szczepienia/artykuly/przegladowe/186457,co-wiadomo-o-populacyjnych-efektach-szczepien-przeciwko-hpv (Accessed: 20.10.2021). 3.
de Martel C, Plummer M, Vignat J, et al. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 2017; 141: 664-670. 4.
de Sanjose S, Quint WG, Alemany L, et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol 2010; 11: 1048-1056. 5.
Nowakowski A, de Souza SC, Jach R, et al. HPV-type distribution and reproducibility of histological diagnosis in cervical neoplasia in Poland. Pathol Oncol Res 2015; 21: 703-711. 6.
https://gco.iarc.fr/causes/infections/tools-pie?mode=2&sex=0&population=who&continent=0&country=0&population_group=0&cancer=0&key=attr_cases&lock_scale=0&pie_mode=1&nb_results=5 (Accessed: 20.10.2021). 7.
World Health Organization. Weekly Epidemiological Record 2017; 92: 241-268. https://apps.who.int/iris/handle/10665/255353. 8.
Stanley M. HPV vaccines: alternative dosage schedules. Expert Rev Vaccines 2019; 18: 1309-1316. 9.
Drolet M, Bénard É, Pérez N, et al. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. Lancet 2019; 394: 497-509. 10.
Gidengil C, Goetz MB, Newberry S, et al. Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis. Vaccine 2021; 39: 3696-3716. 11.
Andrews N, Stowe J, Miller E. No increased risk of Guillain-Barré syndrome after human papilloma virus vaccine: a self-controlled case-series study in England. Vaccine 2017; 35: 1729-1732. 12.
Hviid A, Thorsen NM, Valentiner-Branth P, et al. Association between quadrivalent human papillomavirus vaccination and selected syndromes with autonomic dysfunction in Danish females: population based, self-controlled, case series analysis. BMJ 2020; 370: m2930. 13.
Barboi A, Gibbons CH, Axelrod F, et al. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res 2020; 30: 13-18. 14.
Gøtzsche PC, Jørgensen KJ. EMA’s mishandling of an investigation into suspected serious neurological harms of HPV vaccines. BMJ Evid Based Med 2022; 27: 7-10. 15.
Tatang C, Arredondo Bisonó T, Bergamasco A, et al. Human papillomavirus vaccination and premature ovarian failure: a disproportionality analysis using the vaccine adverse event reporting system. Drugs Real World Outcomes 2022; 9: 79-90. 16.
Bonaldo G, Vaccheri A, D’Annibali O, et al. Safety profile of human papilloma virus vaccines: an analysis of the US Vaccine Adverse Event Reporting System from 2007 to 2017. Br J Clin Pharmacol 2019; 85: 634-643. 17.
Vichnin M, Bonanni P, Klein NP, et al. An overview of quadrivalent human papillomavirus vaccine safety: 2006 to 2015. Pediatr Infect Dis J 2015; 34: 983-991. 18.
Joura EA, Giuliano AR, Iversen OE, et al. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. N Engl J Med 2015; 372: 711-723. 19.
Goss MA, Lievano F, Buchanan KM, et al. Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine. Vaccine 2015; 33: 3422-3428. 20.
Scheller NM, Pasternak B, Mølgaard-Nielsen D, et al. Quadrivalent HPV vaccination and the risk of adverse pregnancy outcomes. N Engl J Med 2017; 376: 1223-1233. 21.
Schwarz TF, Huang LM, Lin TY, et al. Long-term immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in 10-to 14-year-old girls: open 6-year follow-up of an initial observer-blinded, randomized trial. Pediatr Infect Dis J 2014; 33: 1255-1261. 22.
Kjaer SK, Sigurdsson K, Iversen OE, et al. A pooled analysis of continued prophylactic efficacy of quadrivalent human papillomavirus (Types 6/11/16/18) vaccine against high-grade cervical and external genital lesions. Cancer Prev Res (Phila) 2009; 2: 868-878. 23.
Lehtinen M, Paavonen J, Wheeler CM, et al. Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial [published correction appears in Lancet Oncol 2012; 13: e1]. Lancet Oncol 2012; 13: 89-99. 24.
Hildesheim A, Wacholder S, Catteau G, et al. Efficacy of the HPV-16/18 vaccine: final according to protocol results from the blinded phase of the randomized Costa Rica HPV-16/18 vaccine trial. Vaccine 2014; 32: 5087-5097. 25.
Giuliano AR, Palefsky JM, Goldstone S, et al. Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males [published correction appears in N Engl J Med 2011; 364: 1481]. N Engl J Med 2011; 364: 401-411. 26.
Olsson SE, Restrepo JA, Reina JC, et al. Long-term immunogenicity, effectiveness, and safety of nine-valent human papillomavirus vaccine in girls and boys 9 to 15 years of age: Interim analysis after 8 years of follow-up. Papillomavirus Res 2020; 10: 100203. 27.
Kjaer SK, Nygård M, Sundström K, et al. Final analysis of a 14-year long-term follow-up study of the effectiveness and immunogenicity of the quadrivalent human papillomavirus vaccine in women from four nordic countries. EClinicalMedicine 2020; 23: 100401. 28.
Lehtinen M, Apter D, Eriksson T, et al. Effectiveness of the AS04-adjuvanted HPV-16/18 vaccine in reducing oropharyngeal HPV infections in young females-Results from a community-randomized trial. Int J Cancer 2020; 147: 170-174. 29.
Brisson M, Bénard É, Drolet M, et al. Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: a systematic review and meta-analysis of predictions from transmission-dynamic models. Lancet Public Health 2016; 1: e8-e17. 30.
Falcaro M, Castañon A, Ndlela B, et al. The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence: a register-based observational study. Lancet 2021; 398: 2084-2092. 31.
Lei J, Ploner A, Elfström KM, et al. HPV vaccination and the risk of invasive cervical cancer. N Engl J Med 2020; 383: 1340-1348. 32.
Kjaer SK, Dehlendorff C, Belmonte F, et al. Real-world effectiveness of human papillomavirus vaccination against cervical cancer. J Natl Cancer Inst 2021; 113: 1329-1335. 33.
Muñoz-Quiles C, López-Lacort M, Díez-Domingo J, et al. Human papillomavirus vaccines effectiveness to prevent genital warts: a population-based study using health system integrated databases, 2009-2017. Vaccine 2022; 40: 316-324. 34.
Yuill S, Egger S, Smith M, et al. Has human papillomavirus (HPV) vaccination prevented adverse pregnancy outcomes? Population- level analysis after 8 years of a national HPV vaccination program in Australia. J Infect Dis 2020; 222: 499-508. 35.
Dehlendorff C, Baandrup L, Kjaer SK. Real-world effectiveness of human papillomavirus vaccination against vulvovaginal high-grade precancerous lesions and cancers. J Natl Cancer Inst 2021; 113: 869-874. 36.
Chaturvedi AK, Graubard BI, Broutian T, et al. Effect of Prophylactic human papillomavirus (HPV) vaccination on oral HPV infections among young adults in the United States. J Clin Oncol 2018; 36: 262-267. 37.
Denny LA, Franceschi S, de Sanjosé S, et al. Human papillomavirus, human immunodeficiency virus and immunosuppression. Vaccine 2012; 30 Suppl 5: F168-F174. 38.
Tanweer MS, Aljurf M, Savani BN, et al. Lower genital tract precancer and cancer in hematopoietic cell transplant survivors and the role of HPV: a systematic review and future perspectives. Clin Hematol Int 2019; 1: 142-153. 39.
Gómez de la Rosa AG, Quesada López-Fe A, Vilar Chesa M, et al. Efficacy of human papillomavirus vaccination 4 years after conization for high-grade cervical neoplasia. J Low Genit Tract Dis 2021; 25: 287-290. 40.
Di Donato V, Caruso G, Petrillo M, et al. Adjuvant HPV vaccination to prevent recurrent cervical dysplasia after surgical treatment: a meta-analysis. Vaccines (Basel) 2021; 9: 410. 41.
Sand FL, Kjaer SK, Frederiksen K, et al. Risk of cervical intraepithelial neoplasia grade 2 or worse after conization in relation to HPV vaccination status. Int J Cancer 2020; 147: 641-647. 42.
World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem. Geneva; 2020. 43.
European Centre for Disease Prevention and Control. Guidance on HPV vaccination in EU countries: focus on boys, people living with HIV and 9-valent HPV vaccine introduction. Stockholm; 2020. 44.
Meites E, Szilagyi PG, Chesson HW, et al. Human papillomavirus vaccination for adults: updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep 2019; 68: 698-702. 45.
Uchwała nr 10 Rady Ministrów z dnia 4 lutego 2020 r. w sprawie przyjęcia programu wieloletniego pn. Narodowa Strategia Onkologiczna na lata 2020-2030, Dz.U. 2019 poz. 969 [In Polish]. 46.
Rekomendacja nr 128/2021 z dnia 25 listopada 2021 r. Prezesa Agencji Oceny Technologii Medycznych i Taryfikacji w sprawie oceny leku Gardasil, szczepionka przeciw wirusowi brodawczaka ludzkiego [typy 6, 11, 16, 18] we wskazaniu: zapobieganie wystąpienia u osób w wieku od 9 lat: zmian przednowotworowych narządów płciowych (szyjki macicy, sromu i pochwy), zmian przednowotworowych odbytu, raka szyjki macicy oraz raka odbytu, związanych przyczynowo z zakażeniem pewnymi onkogennymi typami wirusa brodawczaka ludzkiego (HPV); brodawek narządów płciowych (kłykcin kończystych) związanych przyczynowo z zakażeniem określonymi typami wirusa brodawczaka ludzkiego [In Polish]. 47.
Rekomendacja nr 54/2021 z dnia 18 maja 2021 r. Prezesa Agencji Oceny Technologii Medycznych i Taryfikacji w sprawie objęcia refundacją leku Cervarix, szczepionka przeciw wirusowi brodawczaka ludzkiego [typy 16 i 18] we wskazaniu: profilaktyka zmian przednowotworowych narządów płciowych i odbytu (szyjki macicy, sromu, pochwy i odbytu) oraz raka szyjki macicy i raka odbytu związanych przyczynowo z określonymi onkogennymi typami wirusa brodawczaka ludzkiego (HPV) u osób od ukończenia 9. roku życia [In Polish]. 48.
Nowakowski A, Arbyn M, Turkot MH, et al. A roadmap for a comprehensive control of cervical cancer in Poland: integration of available solutions into current practice in primary and secondary prevention. Eur J Cancer Prev 2020; 29: 157-164. 49.
Bidziński M, Debski R, Kedzia W, et al. Stanowisko zespołu ekspertów Polskiego Towarzystwa Ginekologicznego na temat profilaktyki raka gruczołowego szyjki macicy. Ginekol Pol 2008; 79: 710-714. 50.
Chybicka A, Jackowska T, Dobrzańska A, et al. Zalecenia grupy ekspertów dotyczące pierwotnej profilaktyki raka szyjki macicy u dziewcząt i młodych kobiet. Pediatr Pol 2010; 85: 360-370. 51.
Agencja Oceny Technologii Medycznych i Taryfikacji, Wydział Oceny Technologii Medycznych. Profilaktyka zakażeń wirusem brodawczaka ludzkiego (HPV) w ramach programów polityki zdrowotnej Warszawa. Raport w sprawie zalecanych technologii medycznych, działań przeprowadzanych w ramach programów polityki zdrowotnej oraz warunków realizacji tych programów polityki zdrowotnej – materiały dla Rady Przejrzystości AOTMiT. Warszawa, 2019 [In Polish]; https://bipold.aotm.gov.pl/assets/files/ppz/2019/RPT/19.10.29_raport_zalec_techn_art_48aa_profilaktyka_hpv.pdf (Accessed: 20.10.2021). 52.
Wydział Zdrowia i Spraw Społecznych Urzędu Miejskiego Wrocławia. Wrocławski program profilaktyki zakażeń wirusem brodawczaka ludzkiego [in Polish]; https://hpv.um.wroc.pl/?p=561 (Accessed: 20.10.2021). 53.
Ludwikowska KM, Szenborn L, Krzyżanowska I, et al. Potrzeba, bezpieczeństwo oraz realizacja szczepień przeciwko HPV – perspektywa wrocławska. Klin Pediatr 2018; 26: 26-30 [In Polish]. 54.
Ludwikowska KM, Biela M, Szenborn L. HPV vaccine acceptance and hesitancy – lessons learned during 8 years of regional HPV prophylaxis program in Wroclaw, Poland. Eur J Cancer Prev 2020; 29: 346-349. 55.
Nguyen-Huu NH, Thilly N, Derrough T, et al. Human papillomavirus vaccination coverage, policies, and practical implementation across Europe. Vaccine 2020; 38: 1315-1331. 56.
Brown B, Gabra MI, Pellman H. Reasons for acceptance or refusal of Human Papillomavirus Vaccine in a California pediatric practice. Papillomavirus Res 2017; 3: 42-45. 57.
Facciolà A, Visalli G, Orlando A, et al. Vaccine hesitancy: an overview on parents’ opinions about vaccination and possible reasons of vaccine refusal. J Public Health Res 2019; 8: 1436.
Copyright: © 2022 Polish Society of Paediatrics. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
|