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3/2014
vol. 95 abstract:
Review paper
Regulation of alternative splicing by RNA secondary structure
Jolanta Lisowiec
,
Grażyna Dominiak
,
Ryszard Kierzek
vol. 95(3) C pp. 181-186 C 2014
Online publish date: 2015/10/06
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The alternative splicing process is controlled by trans-acting factors and cis-acting elements. Initially, it was
thought that hnRNP proteins interact with the newly synthetized transcript and prevent the generation of a premRNA secondary structure. However, there are many examples of the impact of secondary structure on the alternative splicing of genes. An alternative splicing regulation is presented based on: the recognition of 5N and 3N splicing sites and branch sites, regulatory cis-acting elements, long-range interaction. keywords:
alternative splicing, RNA secondary structure, splicing regulatory elements |