eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
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3/2014
vol. 95
 
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abstract:
Review paper

Regulation of alternative splicing by RNA secondary structure

Jolanta Lisowiec
,
Grażyna Dominiak
,
Ryszard Kierzek

vol. 95(3) C pp. 181-186 C 2014
Online publish date: 2015/10/06
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The alternative splicing process is controlled by trans-acting factors and cis-acting elements. Initially, it was

thought that hnRNP proteins interact with the newly synthetized transcript and prevent the generation of a premRNA

secondary structure. However, there are many examples of the impact of secondary structure on the

alternative splicing of genes. An alternative splicing regulation is presented based on: the recognition of 5N and

3N splicing sites and branch sites, regulatory cis-acting elements, long-range interaction.
keywords:

alternative splicing, RNA secondary structure, splicing regulatory elements



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