eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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1/2015
vol. 19
 
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abstract:
Original paper

Relationship between serotonin transporter gene polymorphism and constipation in cancer patients

Weiwei Li
,
Luli Huang
,
Weimei Cai
,
Sue Cao
,
Yan Yuan
,
Sheng Lu
,
Yanzheng Zhao
,
Ping Lu

Contemp Oncol (Pozn) 2015; 19 (1): 17–21
Online publish date: 2015/03/26
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Introduction: To assess the potential association between serotonin transporter gene insertion/deletion polymorphism and the cancer-related constipation phenotype.

Material and methods: A total of 120 patients diagnosed with malignant solid tumors were subjected to genotyping. For the two groups – patients with constipation and constipation-free patients with non-gastrointestinal cancer, 60 cases in each group – we collected the peripheral venous blood. We extracted genomic DNA, and used polymerase chain reaction (PCR) to analyze the serotonin transporter (5-HT) link polymorphic region (5-HTTLPR) polymorphism of the serotonin transporter gene.

Results: The frequency of S/S genotype in cancer patients with constipation was 66.67% (40/60), and the frequency of the S allele was 79.17% (95/120); the frequency of S/S genotype in cancer patients without constipation was 48.33% (29/60), and the frequency of the S allele was 65.83% (79/120). There was a significant difference between the two groups (p < 0.05).

Conclusions: The presence of 5-HTTLPR S/S genotype and the S allele in patients with cancers probably carry an increased risk of constipation. However, its role as a cause of cancer-related constipation needs to be further investigated.
keywords:

cancer, constipation, serotonin transporter, genetic polymorphism

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