eISSN: 2084-9842
ISSN: 1643-9279
Postępy w chirurgii głowy i szyi/Advances in Head and Neck Surgery
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1/2006
vol. 5
 
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abstract:

Research and diagnostic potential of estimation of chromosome instability in laryngeal squamous cell carcinoma

Krzysztof Szyfter
,
Piotr Dąbrowski
,
Marzena Gajęcka
,
Wojciech Gawęcki
,
Maciej Giefing
,
Małgorzata Jarmuż
,
Magdalena Kostrzewska-Poczekaj
,
Katarzyna Szukała
,
Małgorzata Wierzbicka

Post chir głowy i szyi 2006; 1: 53–59
Online publish date: 2006/06/07
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Chromosome instability is a hidden attribute of a cell and/or organism emerging after an exposure to mutagen. There was established the bleomycin test for a qualitative estimation of chromosome instability being also a measure of mutagen sensitivity and further of genetic risk to develop cancer. A review presents application of bleomycin test to estimate a risk a head and cancer focused on laryngeal cancer. Next, an application to detect a tendency to develop secondary tumour and to estimate a cancer risk in young adults is discussed.
keywords:

chromosome instability, bleomycin test, laryngeal cancer
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