eISSN: 2300-6722
ISSN: 1899-1874
Medical Studies/Studia Medyczne
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
4/2023
vol. 39
 
Share:
Share:
abstract:
Original paper

Retinal thickness in patients with elevated D-dimer and interleukin-6 levels as a result of SARS-CoV-2 infection

Magdalena Kal
1, 2
,
Michał Brzdęk
1, 3
,
Mateusz Winiarczyk
4
,
Jerzy Mackiewicz
4
,
Dorota Kozieł
1
,
Dominik Odrobina
2, 5, 6
,
Dorota Zarębska-Michaluk
1, 3

  1. Collegium Medicum, Jan Kochanowski University, Kielce, Poland
  2. Ophthalmic Clinic, Voivodeship Hospital, Kielce, Poland
  3. Department of Infectious Disease, Voivodeship Hospital, Kielce, Poland
  4. Department of Vitreoretinal Surgery, Medical University of Lublin, Lublin, Poland
  5. Institute of Medical Science, Jan Kochanowski University, Kielce, Poland
  6. Ophthalmology Clinic Boni Fratres Lodziensis, Lodz, Poland.
Medical Studies/Studia Medyczne 2023; 39 (4): 342-351
Online publish date: 2023/12/30
View full text Get citation
 
PlumX metrics:
Introduction
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to various health issues, including severe pneumonia, organ damage, as well as effects on the retina. Researchers have detected SARS-CoV-2 in the retinas of infected patients, and new imaging methods, such as optical coherence tomography (OCT), are being used to investigate its impact on the eye.

Aim of the research
To document changes in retinal thickness (RT) and their association with saturation (SpO2), D-dimers, and interleukin-6 (IL-6) levels in coronavirus disease 2019 (COVID-19) patients hospitalized for bilateral pneumonia.

Material and methods
This prospective study included COVID-19 patients assessed after 2 months (Group 1) and re-evaluated after 8 months from hospital discharge (Group 2). RT was automatically assessed with OCT. Group 2 RT measurements were compared with those of healthy subjects, and D-dimers, IL-6, and SpO2 levels on admission were correlated with RT in group 1.

Results
Group 2 exhibited a significant decrease in RT compared to group 1 in specific macular regions, accompanied by an increase in certain areas. Moreover, Group 2 demonstrated increased RT compared to a control group in specific regions. A positive correlation was observed between SpO2 ≤ 90% and RT in Group 1 in specific macular regions.

Conclusions
RT in patients after SARS-CoV-2 infection is altered at the 6-month follow-up. Hypoxia, hypercoagulability, and inflammation in COVID-19 can collectively influence RT.

keywords:

COVID-19, D-dimers, interleukin 6, optical coherence tomography, retinal thickness

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.