eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Contemporary Oncology
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1A/2015
 
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abstract:

Review
Hypoxia-shaped vascular niche for cancer stem cells

Guillaume Collet
,
Bouchra El Hafny-Rahbi
,
Mahdi Nadim
,
Anna Tejchman
,
Krzysztof Klimkiewicz
,
Claudine Kieda

Contemp Oncol (Pozn) 2015; 19 (1A): A39–A43
DOI: https://doi.org/10.5114/wo.2014.47130
Online publish date: 2015/01/20
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The tumour microenvironment, long considered as determining cancer development, still offers research fields to define hallmarks of cancer. An early key-step, the “angiogenic switch”, allows tumour growth. Pathologic angiogene-sis is a cancer hallmark as it features results of tumour-specific properties that can be summarised as a response to hypoxia. The hypoxic state occurs when the tumour mass reaches a volume sufficient not to permit oxygen diffusion inside the tumour centre. Thus tumour cells turn on adaptation mechanisms to the low pO2 level, inducing biochemical responses in terms of cytokines/chemokines/receptors and consequently recruitment of specific cell types, as well as cell-selection inside the tumour. Moreover, these changes are orchestrated by the microRNA balance strongly reflecting the hypoxic milieu and mediating the cross-talk between endothelial and tumour cells. MicroRNAs control of the endothelial precursor-vascular settings shapes the niche for selection of cancer stem cells.
keywords:

angiogenesis, cancer stem cell, endothelial precursor cell, hypoxia, microRNA
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