eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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3/2021
vol. 72
 
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abstract:
Review paper

Review of TFEB-amplified renal cell carcinoma with focus on clinical and pathobiological aspects

Naoto Kuroda
1
,
Emiko Sugawara
2
,
Chisato Ohe
3
,
Fumiyoshi Kojima
4
,
Riuko Ohashi
5
,
Shuji Mikami
6
,
Yoji Nagashima
7
,
Kvetoslava Peckova
8
,
Michal Michal
8
,
Ondrej Hes
8

  1. Department of Diagnostic Pathology, Kobe Kyodo Hospital, Kobe, Japan
  2. Department of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
  3. Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Japan
  4. Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
  5. Histopathology Core Facility, Niigata University Faculty of Medicine, Niigata, Japan
  6. Department of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan
  7. Department of Surgical Pathology, Tokyo Women’s Medical University, Tokyo, Japan
  8. Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Pilsen, Czech Republic
Pol J Pathol 2021; 72 (3): 197-199
DOI: https://doi.org/10.5114/pjp.2021.111769
Online publish date: 2022/01/19
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The disease entity of TFEB-amplified renal cell carcinoma (RCC) has been recently established. In this article, we review such cases. Clinically, the age of patients ranged from 28 to 83 years with a mean age of 62.8 years. The size of the tumor ranged from 1.9 to 19.5 cm with a mean size of 8.7 cm. The tumor demonstrated a variety of architectural patterns such as solid, alveolar, papillary, pseudopapillary, nested or tubular. The International Society of Urological Pathology (ISUP) grade usually corresponds to grade 3 or 4. Cytomorphology shows eosinophilic, clear, amphophilic or even oncocytic cytoplasm. Necrosis can be frequently observed. Neoplastic cells with TFEB-amplified RCC show diffuse or patchy positivity for TFEB. Fluorescence in situ hybridization frequently show the amplification of more than 10 or 20 copies of the TFEB gene. Most TFEB-amplified RCCs behave in an aggressive fashion. Metastasis frequently occurs. In conclusion, this tumor seems to be characterized by occurrence in older patients, frequent necrosis, papillary/pseudopapillary growth pattern, high-grade nuclear grade, TFEB gene amplification, and aggressive clinical behavior. In order to clarify whether this tumor is a distinct entity from previously described renal tumors or not, a further examination in a large scale study will be required in the future.
keywords:

TFEB-amplified, renal cell carcinoma, pathology, review
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