Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma

Andrzej Wincewicz; Artur Kowalik; Sebastian Zięba; Janusz Kopczyński; Stanisław Góźdź; Stanisław Sulkowski

doi:10.5114/pjp.2016.65860

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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abstract:

Review paper

Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma

Andrzej Wincewicz

,

Artur Kowalik

,

Sebastian Zięba

,

Janusz Kopczyński

,

Stanisław Góźdź

,

Stanisław Sulkowski

Pol J Pathol 2016; 67 (4): 307-312

DOI: https://doi.org/10.5114/pjp.2016.65860

Online publish date: 2017/02/10

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AMA

Wincewicz A, Kowalik A, Zięba S, Kopczyński J, Góźdź S, Sulkowski S. Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma. Polish Journal of Pathology. 2016;67(4):307-312. doi:10.5114/pjp.2016.65860.

APA

Wincewicz, A., Kowalik, A., Zięba, S., Kopczyński, J., Góźdź, S.,  & Sulkowski, S. (2016). Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma. Polish Journal of Pathology, 67(4), 307-312. https://doi.org/10.5114/pjp.2016.65860

Chicago

Wincewicz, Andrzej, Artur Kowalik, Sebastian Zięba, Janusz Kopczyński, Stanisław Góźdź,  and Stanisław Sulkowski. 2016. "Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma". Polish Journal of Pathology 67 (4): 307-312. doi:10.5114/pjp.2016.65860.

Harvard

Wincewicz, A., Kowalik, A., Zięba, S., Kopczyński, J., Góźdź, S.,  and Sulkowski, S. (2016). Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma. Polish Journal of Pathology, 67(4), pp.307-312. https://doi.org/10.5114/pjp.2016.65860

MLA

Wincewicz, Andrzej et al. "Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma." Polish Journal of Pathology, vol. 67, no. 4, 2016, pp. 307-312. doi:10.5114/pjp.2016.65860.

Vancouver

Wincewicz A, Kowalik A, Zięba S, Kopczyński J, Góźdź S, Sulkowski S. Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma. Polish Journal of Pathology. 2016;67(4):307-312. doi:10.5114/pjp.2016.65860.

PlumX metrics:

Here we review prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology on the basis of the morphological report and molecular analysis of adult nephroblastoma (diffuse blastemal pattern) of a 37-year-old man. Among quite different proteins, TP53 affects expression of several genes such as hypoxia inducible proteins GLUT1 and EPO as well as multidrug resistance (MDR) mediated by P-glycoprotein (Pgp/MDR1) and multidrug-resistant related protein (MRP1), with certain clinical implications. TP53 mutation was found both in our primary tumor (c.746G>T p.R249M frequency 92%) and in nodal metastasis (c.746G>T p.R249M frequency 90%), and the common polymorphism p.P72R in the same gene was revealed with frequency of about 97% in both primary tumor and metastatic disease with appliance of NGS technology (IonTorrent – LifeTechnology) using Ion AmpliSeq Cancer Hotspot Panel v2.

keywords:

Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma

Andrzej Wincewicz , Artur Kowalik , Sebastian Zięba , Janusz Kopczyński , Stanisław Góźdź , Stanisław Sulkowski

nephroblastoma, histopathological typing, staging, TP53 mutation

Andrzej Wincewicz

,

Artur Kowalik

,

Sebastian Zięba

,

Janusz Kopczyński

,

Stanisław Góźdź

,

Stanisław Sulkowski