eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
4/2013
vol. 64
 
Share:
Send email
Share:
abstract:

Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects

Naoto Kuroda
,
Hirofumi Matsumoto
,
Chisato Ohe
,
Shuji Mikami
,
Yoji Nagashima
,
Keiji Inoue
,
Delia Perez-Montiel
,
Fredrik Petersson
,
Michal Michal
,
Ondrej Hes
,
Ximing J. Yang

POL J PATHOL 2013; 64 (4): 233-237
DOI: https://doi.org/10.5114/pjp.2013.39329
Online publish date: 2013/12/26
View full text Get citation
 
PlumX metrics:
Tubulocystic carcinoma of the kidney (TCK) is a recently established entity in renal neoplastic pathology. This review aims to give an overview of the clinical and pathobiological aspects of TCK. Grossly, the TCKs are well-demarcated multicystic lesions giving a “wrapped bubble” or “spongy” appearance. Microscopically, the tumors are composed of multiple, variably sized cysts separated by thin fibrous septa lacking ovarian stroma or desmoplastic reaction. The cysts are lined by tumor cells with eosinophilic cytoplasm and nuclear atypia of variable, but not infrequently of high grade corresponding to Fuhrman grade 3. A frequent association with papillary tumors has been reported. Recent molecular genetic studies of TCK have revealed distinct features separating this subset of renal cell carcinomas (RCCs) from other types of renal tumors including collecting duct carcinoma of Bellini and renal medullary carcinoma as well as pointing towards a close kinship with papillary RCC. Tubulocystic carcinoma of the kidney generally pursues an indolent clinical course. However, several cases with aggressive clinical behavior have been reported. We strongly feel that there is enough clinicopathological evidence to corroborate TCK as a separate entity and that it should be incorporated into the next WHO classification of renal tumors as a separate neoplastic category.
keywords:

tubulocystic carcinoma, kidney, new entity
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.