Review paper<br>Chronic ulcerative stomatitis – pathogenesis, clinical manifestations and therapy

Magdalena Szymanek; Dorota Krasowska

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper
Chronic ulcerative stomatitis – pathogenesis, clinical manifestations and therapy

Magdalena Szymanek

,

Dorota Krasowska

Post Dermatol Alergol 2009; XXVI, 6: 518-521

Online publish date: 2010/01/04

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Chronic ulcerative stomatitis (CUS) is a rare mucocutaneous disease. It is characterized by the presence of chronic painful oral erosive or ulcerative lesions with relapses. The most commonly affected areas are the tongue, buccal mucosa and the gingiva. A diagnosis of CUS is made based on the characteristic direct immunofluorescence findings – the presence of IgG antibodies bound to nuclei of keratinocytes of the basal and parabasal cell layers, with the unique stratified epithelial specific-antinuclear antibody (SES-ANA) pattern. Indirect immunofluorescence, with monkey and guinea pig oesophagus as substrates, is used to confirm the diagnosis. In the treatment of CUS, hydroxychloroquine alone or with small doses of corticosteroids is found to be the drug of choice in limiting the disease.

keywords:

Review paperChronic ulcerative stomatitis – pathogenesis, clinical manifestations and therapy

Magdalena Szymanek , Dorota Krasowska

oral diseases, stratified epithelial-specific antinuclear antibodies, direct immunofluorescence, indirect immunofluorescence, hydroxychloroquine

Review paper
Chronic ulcerative stomatitis – pathogenesis, clinical manifestations and therapy

Magdalena Szymanek

,

Dorota Krasowska