Review paper<br>Current views on the mechanisms of immune responses to trauma and infection

Aneta Małgorzata Binkowska; Grzegorz Michalak; Robert Słotwiński

doi:10.5114/ceji.2015.52835

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

2/2015
vol. 40

Send email

Copy url:

abstract:

Review paper
Current views on the mechanisms of immune responses to trauma and infection

Aneta Małgorzata Binkowska

,

Grzegorz Michalak

,

Robert Słotwiński

(Centr Eur J Immunol 2015; 40 (2): 206-216)

DOI: https://doi.org/10.5114/ceji.2015.52835

Online publish date: 2015/08/03

View full text Get citation

PlumX metrics:

According to the World Health Organization, post-traumatic mortality rates are still very high and show an increasing tendency. Disorders of innate immune response that may increase the risk of serious complications play a key role in the immunological system response to trauma and infection. The mechanism of these disorders is multifactorial and is still poorly understood. The changing concepts of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) early inflammatory response, presented in this work, have been extended to genetic studies. Overexpression of genes and increased production of immune response mediators are among the main causes of multiple organ dysfunction syndrome (MODS). Changes in gene expression detected early after injury precede the occurrence of subsequent complications with a typical clinical picture. Rapid depletion of energy resources leads to immunosuppression and persistent inflammation and immune suppression catabolism syndrome (PICS). Early diagnosis of immune disorders and appropriate nutritional therapy can significantly reduce the incidence of complications, length of hospital stay, and mortality. The study presents the development of knowledge and current views explaining the mechanisms of the immune response to trauma and infection.

keywords:

Review paperCurrent views on the mechanisms of immune responses to trauma and infection

Aneta Małgorzata Binkowska , Grzegorz Michalak , Robert Słotwiński

sepsis, SIRS, CARS, PICS, MODS, innate immune response

Review paper
Current views on the mechanisms of immune responses to trauma and infection

Aneta Małgorzata Binkowska

,

Grzegorz Michalak

,

Robert Słotwiński