Review paper<br>DNA and RNA oligonucleotides as a new class of drugs

Dorota Radomska-Leśniewska; Agata Hevelke; Ewa Jankowska-Steifer; Jacek Malejczyk

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2009
vol. 34

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Review paper
DNA and RNA oligonucleotides as a new class of drugs

Dorota Radomska-Leśniewska

,

Agata Hevelke

,

Ewa Jankowska-Steifer

,

Jacek Malejczyk

Centr Eur J Immunol 2009; 34 (4): 280-283

Online publish date: 2009/12/30

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Aptamers are short synthetic single-stranded DNA or RNA oligonucleotides forming unique 3-D conformation. They are able to bind and neutralize their target molecules with high specificity and affinity. Therefore, they may specifically interfere in vivo with some protein function and thus display drug-like properties. This paper provides a brief description of possible clinical application of aptamers arguing for their tremendous therapeutic possibilities.

keywords:

Review paperDNA and RNA oligonucleotides as a new class of drugs

Dorota Radomska-Leśniewska , Agata Hevelke , Ewa Jankowska-Steifer , Jacek Malejczyk

aptamer, DNA, RNA, cancer therapy, ocular diseases, viral diseases, circulations disorders

Review paper
DNA and RNA oligonucleotides as a new class of drugs

Dorota Radomska-Leśniewska

,

Agata Hevelke

,

Ewa Jankowska-Steifer

,

Jacek Malejczyk