eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2010
vol. 35
 
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abstract:

Review paper
Embryonic stem cells and retinal regeneration

Małgorzata Woronkowicz
,
Piotr Skopiński

(Centr Eur J Immunol 2010; 35 (4): 267-272)
Online publish date: 2011/01/13
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The potential of embryonic stem cells (ESCs) to differentiate into various cell types make them prime candidates to play an important role in the future of regenerative medicine. A wide range of retinal degenerative diseases which are the leading cause of irreversible blindness worldwide may be potentially treated by stem cell therapies. Common retinal neurodegenerative pathologies mainly affect one of three ocular cell types: ganglion cells (e.g. glaucoma), photoreceptors (e.g. retinitis pigmentosa) and retinal pigment epithelium (RPE) cells (e.g. age-related macular degeneration). This article summarizes the latest advances made in embryonic stem cell-based medicine for retinal diseases and presents some obstacles which need to be overcome before ESCs can be used safely and effectively.
keywords:

embryonic stem cells, retina, RPE, photoreceptors, ganglion cells, regenerative medicine
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