Review paper<br>Obesity, adipose tissue function and the role of vitamin D

Aneta U. Koszowska; Justyna Nowak; Anna Dittfeld; Anna Brończyk-Puzoń; Agata Kulpok; Barbara Zubelewicz-Szkodzińska

doi:10.5114/ceji.2014.43732

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2014
vol. 39

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abstract:

Review paper
Obesity, adipose tissue function and the role of vitamin D

Aneta U. Koszowska

,

Justyna Nowak

,

Anna Dittfeld

,

Anna Brończyk-Puzoń

,

Agata Kulpok

,

Barbara Zubelewicz-Szkodzińska

(Centr Eur J Immunol 2014; 39 (2): 260–264)

DOI: https://doi.org/10.5114/ceji.2014.43732

Online publish date: 2014/06/27

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Introduction: Obesity is not just a cosmetic problem. Pathological accumulation of body fat can cause many health problems: insulin resistance, impaired glucose tolerance, and diabetes mellitus type 2. It may also increase morbidity and mortality. Adipose tissue plays an important role in body homeostasis by producing and secreting several bioactive proteins known as adipokines: adiponectin, leptin, resistin, visfatin, and apelin, which are involved in the regulation of food intake, glucose and lipid metabolism, and insulin action. There can be observed nutritional deficiencies, despite increased food intake, in morbidly obese people. Data concerning concentrations of serum 25(OH)D3 presented an inverse correlation with obesity parameters like: BMI (body mass index), waist circumference, fat mass or percentage of body fat. Also, higher insulin sensitivity was associated with higher concentrations of vitamin D.

Conclusions: Studies published up to now suggest that vitamin D plays an important role in adipose tissue function and could be involved in the synthesis and modulation of adipokine production. This article is a review of the literature on fatty tissue function and the role of vitamin D in obesity.

keywords:

Review paperObesity, adipose tissue function and the role of vitamin D

Aneta U. Koszowska , Justyna Nowak , Anna Dittfeld , Anna Brończyk-Puzoń , Agata Kulpok , Barbara Zubelewicz-Szkodzińska

obesity, vitamin D, fatty tissue, adipokines

Review paper
Obesity, adipose tissue function and the role of vitamin D

Aneta U. Koszowska

,

Justyna Nowak

,

Anna Dittfeld

,

Anna Brończyk-Puzoń

,

Agata Kulpok

,

Barbara Zubelewicz-Szkodzińska