en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank


Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
2/2008
vol. 46
 
Share:
Send email
Share:
abstract:

Review paper
Progressive multifocal leukoencephalopathy and biological treatment

Leszek Szczepański
,
Anna Szczepańska-Szerej

Reumatologia 2008; 46, 2: 91–94
Online publish date: 2008/04/25
View full text Get citation
 
Progressive multifocal leukoencephalopathy (PML) is severe, rare disease of the brain. It is caused by polyoma virus JVC that belongs to the Papovaviridae family. Mechanism of the disease is the involvement and the impairment of T-helper cells. Numerous focal plaques of demyelinisation develop in central nervous system white matter after the reactivation of JVC virus. The most cases of PML occurred among patients infected by HIV or with lymphoproliferative diseases. Lastly some reports of PML development during biological therapy of SM and Crohn disease were reported. PML was unexpectedly observed in 3 among 3000 cases treated with natalizumab the drug blocking alpha4beta1 integrins in bone marrow and spleen. Natalizumab was withdrawn from clinical studies in early 2005. Biological drugs cause deep perturbation in the immune system. Administration of the drug can be accompanied with PML or similar, severe infections. A high state of vigilance will be required during the treatment by these agents.
keywords:

progressive multifocal leukoencephalopathy, biological treatment, rheumatoid arthritis, systemic lupus erythematodes, natalizumab
EVENTS/KONFERENCJE
BOOKS/KSIĄŻKI



Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.