eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2011
vol. 28
 
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abstract:

Review paper
Herpes simplex virus infection as a possible modulator of autoimmune diseases facilitated by human endogenous retroviruses

Aleksandra Larek-Rąpała
,
Ryszard Żaba
,
Michał Jacek Kowalczyk
,
Beata Szramka-Pawlak
,
Robert A. Schwartz

Post Dermatol Alergol 2011; XXVIII, 4: 313–316
Online publish date: 2011/08/31
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The etiology of many autoimmune diseases such as systemic lupus erythematosus, progressive systemic sclerosis (scleroderma), and psoriasis vulgaris remains unclear. Human endogenous retroviruses (HERVs) may be involved in the development of autoimmune disease. Some exogenous infections, such as herpes simplex virus, appear to be HERV activating factors. A possible relationship will be discussed between herpes simplex virus infection and the development of selected autoimmune diseases through a suggested mechanism facilitated by HERVs.
keywords:

systemic lupus erythematosus, systemic scleroderma, psoriasis vulgaris, human endogenous retrovirus, human herpes simplex virus

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