Review paper<br>
Place of methotrexate in the treatment of psoriasis in the era of biologic agents

Aleksandra Dańczak-Pazdrowska

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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3/2012
vol. 29

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abstract:

Review paper
Place of methotrexate in the treatment of psoriasis in the era of biologic agents

Aleksandra Dańczak-Pazdrowska

Postep Derm Alergol 2012; XXIX, 3: 182–188
[Polish version: Postep Derm Alergol 2012; XXIX, 3: 189-195]

Online publish date: 2012/07/27

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Methotrexate (MTX) belongs to a group of drugs known as antimetabolites and is a structural analog of folic acid. It was used for the first time for the treatment of psoriasis over 50 years ago. Nowadays it is used in every type of moderate-to-severe psoriasis, including psoriatic arthritis, and is considered as the most effective disease modifying drug (DMARD). In this paper we review the current state of knowledge as regards mechanisms of action, effectiveness and toxicity of MTX in psoriatic patients as well as we present ways of its administration.

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Review paper Place of methotrexate in the treatment of psoriasis in the era of biologic agents

Aleksandra Dańczak-Pazdrowska

psoriasis, methotrexate, cyclosporine, biologic therapy

Review paper
Place of methotrexate in the treatment of psoriasis in the era of biologic agents