Rhabdomyosarcoma in children in the light of isotope ratio mass spectrometry

Katarzyna Taran; Tomasz Frączek; Anna Sitkiewicz; Piotr Paneth; Józef Kobos

doi:10.5114/pjp.2015.57251

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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4/2015
vol. 66

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abstract:

Original paper

Rhabdomyosarcoma in children in the light of isotope ratio mass spectrometry

Katarzyna Taran

,

Tomasz Frączek

,

Anna Sitkiewicz

,

Piotr Paneth

,

Józef Kobos

Pol J Pathol 2015; 66 (4): 383-388

DOI: https://doi.org/10.5114/pjp.2015.57251

Online publish date: 2016/02/05

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Rhabdomyosarcoma is the third most common solid tumor in children and the most common soft tissue sarcoma in this age group. However, 5-year survival is only observed in approximately 70% of cases, and the prognosis for patients with progressive disease is still poor. The authors hypothesize that the still unidentified differences in embryonal and alveolar tumor biology reflect the complex chemical reactions occurring during cell growth and metabolism and may be pursued in isotopic fractionation processes. Presented herein is the first evaluation of the nitrogen and carbon isotope ratio using isotope ratio mass spectrometry in the two major rhabdomyosarcoma histologic types. ¹⁵N enrichment was found in tumor tissues of embryonal histological type. The obtained result may indicate that individual patient considerations such as isotope ratio, in addition to widely accepted prognostic factors, may facilitate patient classification in terms of risk groups.

keywords:

Rhabdomyosarcoma in children in the light of isotope ratio mass spectrometry

Katarzyna Taran , Tomasz Frączek , Anna Sitkiewicz , Piotr Paneth , Józef Kobos

rhabdomyosarcoma, childhood, spectrometry, isotopes, prognosis

Katarzyna Taran

,

Tomasz Frączek

,

Anna Sitkiewicz

,

Piotr Paneth

,

Józef Kobos