Rituximab in haematology and oncology in 10 years of experience

Anna Wache; Lidia Gil; Mieczysław Komarnicki

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2008
vol. 12

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abstract:

Rituximab in haematology and oncology in 10 years of experience

Anna Wache

,

Lidia Gil

,

Mieczysław Komarnicki

Współczesna Onkologia (2008) vol. 12; 4 (173-178)

Online publish date: 2008/07/22

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Rituximab, a chimeric anti-CD20 monoclonal antibody, used as a single agent or in combination with chemotherapy, has resulted in significant responses in patients with almost every subtype of B-cell lymphoma. Its modulation effects on the immune system have prompted its use in non-neoplastic diseases. Here, based on 10 years of experience, we summarize label and off-label use of rituximab in oncology and haematology. Rituximab mechanisms of action and resistance are discussed.

keywords:

Rituximab in haematology and oncology in 10 years of experience

Anna Wache , Lidia Gil , Mieczysław Komarnicki

rituximab, B-cell lymphoma, autoimmune haematological disorders

Anna Wache

,

Lidia Gil

,

Mieczysław Komarnicki