Angiogenesis in neoplastic processes

Paweł Sadłecki; Małgorzata Walentowicz-Sadłecka; Marek Grabiec

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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1/2010
vol. 9

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abstract:

Review paper

Angiogenesis in neoplastic processes

Paweł Sadłecki

,

Małgorzata Walentowicz-Sadłecka

,

Marek Grabiec

Przegląd Menopauzalny 2010; 1: 28–31

Online publish date: 2010/02/25

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Angiogenesis, the formation of new blood vessels from existing vasculature, is a complex multi-step process initiated by the secretion and action of soluble angiogenic factors. Thus degradation of extracellular matrix proteins and activation, proliferation, migration and organization into tubular structures of vascular endothelial cells and pericytes takes place. Formation of new blood vessels plays a key role in physiological processes involving neovascularization, such as ovulation, placentation and embryogenesis. Moreover, angiogenesis is crucial for benign and malignant neoplastic processes. Invasive cancer growth occurs as a result of formation of blood vessels within a tumour that enable its growth, infiltration of tissues and genesis of metastases.

keywords:

Angiogenesis in neoplastic processes

Paweł Sadłecki , Małgorzata Walentowicz-Sadłecka , Marek Grabiec

angiogenesis, neoplasms, pro-angiogenic factors

Paweł Sadłecki

,

Małgorzata Walentowicz-Sadłecka

,

Marek Grabiec