Role of aspartate aminotransferase to platelet ratioin prediction of intrahepatic cholestasis of pregnancy

Nizamettin Bozbay; Şeyma Kılıç; Osman Yildirim; Aybike Tazegül Pekin; Gökçen Örgül

doi:10.5114/ceh.2024.145447

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Role of aspartate aminotransferase to platelet ratioin prediction of intrahepatic cholestasis of pregnancy

Nizamettin Bozbay

¹

,

Şeyma Kılıç

¹

,

Osman Yildirim

¹

,

Aybike Tazegül Pekin

¹

,

Gökçen Örgül

¹

Selcuk University Faculty of Medicine, Turkey

Clin Exp HEPATOL 2024; 10, 4:

DOI: https://doi.org/10.5114/ceh.2024.145447

Online publish date: 2024/12/02

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Aim of the study:
We aimed to compare the first, second and third trimester APRI (aspartate aminotransferase to platelet ratio index) scores in pregnant women with and without intrahepatic cholestasis (ICH).

Material and methods:
In this study, 54 patients diagnosed with ICH and 59 healthy pregnant women admitted to a tertiary care center between 2018 and 2024 were evaluated. APRI scores were compared between the two groups for three trimesters (first, second, and third trimester). The optimal cut-off values of the APRI score for the prediction of ICH were analyzed.

Results:
APRI scores were significantly higher in the ICH group in all trimesters (p = 0.028, p < 0.001, p < 0.001, respectively). The optimal cut-off value for APRI score to predict ICH in the first, second, and third trimesters was 0.06 (42.6% sensitivity, 83.1% specificity), 0.1 (57.4% sensitivity, 93.2% specificity) and 13 (77.8% sensitivity, 98.3% specificity), respectively.

Conclusions:
APRI score was found to be a significant predictor of ICH throughout the entire pregnancy. APRI score seems to be a useful marker in clinical practice to predict ICH.

keywords:

Role of aspartate aminotransferase to platelet ratioin prediction of intrahepatic cholestasis of pregnancy

Nizamettin Bozbay 1 , Şeyma Kılıç 1 , Osman Yildirim 1 , Aybike Tazegül Pekin 1 , Gökçen Örgül 1

pregnancy, bile acids, intrahepatic cholestasis, APRI score

Nizamettin Bozbay

¹

,

Şeyma Kılıç

¹

,

Osman Yildirim

¹

,

Aybike Tazegül Pekin

¹

,

Gökçen Örgül

¹