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4/2023
vol. 98 abstract:
Original paper
Role of epicardial fat thickness and irisin levels in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus
Abeer M. Nour ElDin Abd ElBaky
1
,
Nagwa Abdallah Ismail
1
,
Azza M.O. AbdelRahman
1
,
Sally A.F. EL-Sahrigy
1
,
Rasha M. Hasanin
1
,
Hoda H. Ahmed
1
,
Maha M.A. Abo Hashesh
1
,
Mona Hamed Ibrahim
2
Pediatr Pol 2023; 98 (4): 278-284
Online publish date: 2023/12/15
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Introduction
to assess the role of epicardial fat thickness and irisin in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus and correlate them with echocardiographic parameters and lipid profile. Material and methods Sixty-three type 1 diabetic children and adolescents were recruited from the Pediatric Diabetic Clinic, National Research Centre. Thirty-four healthy children, matched for age and sex, served as controls. All patients were insulin dependent with at least 3-year duration of the disease since diagnosis. Venous blood was withdrawn under complete aseptic precautions from fasting subjects; sera were collected for evaluation of glycated haemoglobin (HbA1C), lipid profile and irisin levels. Two-dimensional echocardiography was performed for measurement of interventricular septal thickness in diastole, left atrial diameter (LAD), aortic root diameter, mitral E and A wave, left ventricular internal dimension in diastole, percent fractional shortening (FS%), percent ejection fraction, left ventricular mass, and epicardial fat thickness. Patients were further divided into two groups according to their glycaemic control (< 7.00, ≥ 7.0) for comparison of echocardiographic parameters and irisin. Results Echocardiographic study revealed a statistically significant increase in LAD, FS%, and epicardial fat thickness in patients compared to controls (p = 0.000, 0.014, and 0.000 respectively). Triglyceride and irisin levels were significantly increased in patients compared to controls (p = 0.012, 0.015 respectively). Epicardial fat thickness positively correlated with left atrial diameter (p = 0.009) and left ventricular mass (p = 0.000). Irisin was positively correlated with E/A ratio (p = 0.05). Conclusions The findings of the present study probably indicate the beginning of a state of metabolically induced diastolic dysfunction. Echocardiography should be performed in type 1 diabetic patients on a regular basis for early detection of subclinical cardiac dysfunction. keywords:
epicardial fat thickness, type 1 diabetes mellitus, cardiac dysfunction, children |
POLSKI
