Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005

Magdalena Pęcak; Elżbieta Pluta; Marcin Hetnał; Renata Wróbel-Radecka; Agnieszka Szadurska; Piotr Brandys; Andrzej Kukiełka; Tomasz Dąbrowski; Tomasz Walasek; Jan Skołyszewski

doi:10.5114/wo.2014.43155

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2014
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abstract:

Original paper

Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005

Magdalena Pęcak

,

Elżbieta Pluta

,

Marcin Hetnał

,

Renata Wróbel-Radecka

,

Agnieszka Szadurska

,

Piotr Brandys

,

Andrzej Kukiełka

,

Tomasz Dąbrowski

,

Tomasz Walasek

,

Jan Skołyszewski

Contemp Oncol (Pozn) 2014; 18 (3): 182–186

DOI: https://doi.org/10.5114/wo.2014.43155

Online publish date: 2014/06/18

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AMA

Pęcak M, Pluta E, Hetnał M, et al. Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005. Contemporary Oncology/Współczesna Onkologia. 2014;18(3):182-186. doi:10.5114/wo.2014.43155.

APA

Pęcak, M., Pluta, E., Hetnał, M., Wróbel-Radecka, R., Szadurska, A.,  & Brandys, P. et al. (2014). Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005. Contemporary Oncology/Współczesna Onkologia, 18(3), 182-186. https://doi.org/10.5114/wo.2014.43155

Chicago

Pęcak, Magdalena, Elżbieta Pluta, Marcin Hetnał, Renata Wróbel-Radecka, Agnieszka Szadurska, Piotr Brandys,  and Andrzej Kukiełka et al. 2014. "Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005". Contemporary Oncology/Współczesna Onkologia 18 (3): 182-186. doi:10.5114/wo.2014.43155.

Harvard

Pęcak, M., Pluta, E., Hetnał, M., Wróbel-Radecka, R., Szadurska, A., Brandys, P., Kukiełka, A., Dąbrowski, T., Walasek, T.,  and Skołyszewski, J. (2014). Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005. Contemporary Oncology/Współczesna Onkologia, 18(3), pp.182-186. https://doi.org/10.5114/wo.2014.43155

MLA

Pęcak, Magdalena et al. "Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005." Contemporary Oncology/Współczesna Onkologia, vol. 18, no. 3, 2014, pp. 182-186. doi:10.5114/wo.2014.43155.

Vancouver

Pęcak M, Pluta E, Hetnał M, Wróbel-Radecka R, Szadurska A, Brandys P et al. Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005. Contemporary Oncology/Współczesna Onkologia. 2014;18(3):182-186. doi:10.5114/wo.2014.43155.

PlumX metrics:

Aim of the study is to evaluate the results of postoperative radiotherapy of paragangliomas, prognostic factors and causes of treatment failure.

Material and methods: Forty-four patients (39 females and 5 males) aged 20 to 74 years were treated for paraganglioma between 1970 and 2010 at the Centre of Oncology in Kraków. Patient survival probability was estimated with the Kaplan-Meier method. Log-rank tests and Cox proportional hazard model were used in univariate and multivariate analysis, respectively.

Results: The most common locations of paragangliomas were the following: the ear, carotid body and internal jugular vein bulb. Forty (91%) out of them were benign and 4 – malignant. All patients underwent surgery followed by adjuvant radiotherapy. The delivered dose ranged from 50 to 72 Gy, the mean dose was 60 Gy. Five-year overall survival was 84%. Five-year relapse-free survival was 84%, either. The multivariate analysis has shown that the dose in an independent prognostic factor for the overall survival. The univariate analysis has shown significantly higher 5-year overall survival in patients who received a dose of 60 Gy or higher – 92% vs. 70% in patients who received a dose lower than 60 Gy.

Conclusions: Postoperative radiotherapy with doses higher than 60 Gy in patients with paragangliomas is associated with longer overall survival.

keywords:

Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970–2005

Magdalena Pęcak , Elżbieta Pluta , Marcin Hetnał , Renata Wróbel-Radecka , Agnieszka Szadurska , Piotr Brandys , Andrzej Kukiełka , Tomasz Dąbrowski , Tomasz Walasek , Jan Skołyszewski

head and neck tumours, paragangliomas, chemodectoma, radiotherapy

Magdalena Pęcak

,

Elżbieta Pluta

,

Marcin Hetnał

,

Renata Wróbel-Radecka

,

Agnieszka Szadurska

,

Piotr Brandys

,

Andrzej Kukiełka

,

Tomasz Dąbrowski

,

Tomasz Walasek

,

Jan Skołyszewski